胰岛素样生长因子2研究进展  

Progress on Insulin-like Growth Factor 2

作　　者：王丁科[1] 阎萍[1] 梁春年[1] 曾玉峰[1] 裴杰[1] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所,甘肃兰州730050

出　　处：《动物医学进展》2008年第7期67-70,共4页Progress In Veterinary Medicine

基　　金：甘肃省农牧厅农业生物技术研究与应用开发项目(GNSW-2006-10);中央级公益性科研院所基本科研业务费专项资金项目(BRF060101)

摘　　要：胰岛素样生长因子2(IGF2)是迄今所知功能最复杂的生长调控因子,它能促进细胞的有丝分裂和分化,参与生后基因组重建,与X染色体的失活有重要关系。所有的这些功能说明IGF2在机体生长发育过程中的重要性。此外,IGF2与个体生长速度、瘦肉率、背膘厚等生产性能关系密切,在某些物种已经被作为候选基因确定下来。作为重要的印记基因,IGF2的表达状况与肿瘤,以及潜在肿瘤的发生发展关系密切,在肿瘤治疗方面起重要作用。文章综述了IGF2的基因结构、生物学作用、基因印记、生长发育和肿瘤的关系等方面的研究进展。Insulin-like growth factor 2 （IGF2） is perhaps the most intricate growth regulation factor characterized to date. It can stimulate growth and differentiation in many cells. It participates postnatal restitution and plays an important role in X chromosome inactivation. All of these functions to IGF2 demonstrate that it is very important in growth and development. In addition, IGF2 is important in certain performance trait like growth velocity, lean meat rate, back-rat thick, in some species, it have been determined as a candidate gene. The expression of IGF2, a very important imprinting gene, is associated with growth and development of present and potential tumors, and is very important to healing. This review focused on the IGF2 gene structures, biological functions,gene imprinting, relations to growth and development and to tumors.

关 键 词：胰岛素样生长因子2 生长发育 基因印记 

分 类 号：Q578[生物学—生物化学] Q516