中药白芨对变链菌产酸和黏附影响的实验研究  

Experimental study of Bletille striata Reichb.f decoction against streptococcus mutans on acidogenicity and adhesion

作　　者：陈玉[1] 张晓芳[2] 朱剑东[2] 

机构地区：[1]沈阳医学院奉天医院,辽宁沈阳110024 [2]中国医科大学口腔医学院,辽宁沈阳110002

出　　处：《牙体牙髓牙周病学杂志》2008年第7期390-392,共3页Chinese Journal of Conservative Dentistry

基　　金：辽宁省教育厅课题(202013176)

摘　　要：目的:研究白芨水煎剂(BSD)对变链菌的产酸和黏附是否具有抑制作用,初步探讨中药白芨防龋作用的机理。方法:利用液体稀释法测出MIC值,选取MIC值以下4个浓度梯度,分别加入含有变链菌的培养基中,用pH计测定培养前后上清液的△pH值,并用比浊法观察其对变链菌黏附的影响。结果:△pH值实验前后与对照组相比有显著性差异(P<0.05),白芨水煎剂对变链菌的黏附抑制率最高为66.67%。结论:白芨水煎剂具有抑制变链菌产酸和黏附的作用。AIM： To investigate the inhibitory effect of Bletille striata Reichb. f decoction （BSD） against Streptococcus mutans （S mutans ） on acidogenicity and adhesion in vitro and to explore its cariostatic mechanism. METHODS： Liquid dilution method was adopted to get the minimal inhibitory concentration（MIC）. We selected four different concentration BSDs which were sub - MIC and added them into liquid TS, and measured the pH of superna- tants and calculated △pH. Turbidimetry assay was used to study the inhibitory of adhesion. RESULTS： △pH of the experimerctal group was significantly different from that of the control group（ P 〈0.05 ）. The top inhibitory ratio of adhesion was 66.67%. CONCLUSION ： BSD has inhibitory effect on acidogenicity and adhesion.

关 键 词：白芨 变链菌 产酸和黏附 

分 类 号：R780.2[医药卫生—口腔医学]