锌指基因217与肿瘤  

Zinc Finger Gene 217 and Tumor

作　　者：郑志芳[1] 朱世泽[1] 

机构地区：[1]福建医科大学第二临床医学院,福建省泉州市362000

出　　处：《医学分子生物学杂志》2008年第4期361-364,共4页Journal of Medical Molecular Biology

基　　金：福建省自然科学基金(No.C0410027);福建省教育厅科技项目(No.JAO5270);泉州市科技计划项目(No.2007Z48)~~

摘　　要：锌指基因217(zinc finger gene217,ZNF217)定位于染色体20q13.2,在各种肿瘤如乳腺癌、卵巢癌、胃癌中过度扩增,且与肿瘤的浸润性关系密切。ZNF217的过度扩增能减弱由端粒功能障碍和阿霉素引起的凋亡信号,引起Akt的磷酸化增加,促进肿瘤的发生和生长。抑制ZNF217能增加细胞对阿霉素的敏感性。ZNF217是一转录阻遏蛋白,能募集CtBP1/2并通过其锌指结构与启动子相结合,调节基因的转录。这些基因与细胞分化和增殖有关。目前由于缺乏明确的ZNF217靶向基因,ZNF217的功能尚不完全清楚。The zinc finger gene, ZNF217, located on chromosome 20q13.2, is frequently amplified in a variety of cancer types, including breast, ovarian and gastric cancer, and is associated with aggressive tumor behavior. Over-expressed ZNF217 attenuates apoptotic signals resulting from telomere dysfunction and doxorubicin-induced DNA damage, induces increased phosphorylation of Akt, and promotes neoplastic transformation. Silencing ZNF217 with siRNA restores the sensitivity of cells to doxorubicin. ZNF217, as a transcriptional repressor protein, associates with gene promoters via its zinc fingers and recruits CtBP1/2 to the promoter regions. Interestingly, many genes that are bound by ZNF217 play critical roles in cellular differentiation and proliferation. Presently, the function of ZNF217 is not yet well characterized due to a lack of known target genes.

关 键 词：锌指基因 转录阻遏 癌基因 

分 类 号：R730.2[医药卫生—肿瘤]