帕米膦酸二钠联合放疗治疗骨转移癌的疗效观察  

A clinical trial of disodium pamidronate combined with radiotherpy in treatment of bone metastatic cancer

作　　者：李晓莹 王阁[2] 全晋[2] 

机构地区：[1]六盘水市水城矿业集团总医院肿瘤科,贵州六盘水553001 [2]第三军医大学大坪医院野战外科研究所肿瘤中心,重庆400042

出　　处：《现代肿瘤医学》2008年第8期1401-1403,共3页Journal of Modern Oncology

摘　　要：目的:观察帕米膦酸二钠(博宁)联合放射治疗骨转移癌所致骨痛和高血钙的疗效。方法:对照组30例骨转移癌患者行单纯常规放疗,DT30GY/3GY/10f;治疗组34例骨转移癌患者行放射治疗前给予帕米膦酸二钠90mg加入生理盐水中缓慢静脉滴注4-6h(可分为2天用药),接着行放射治疗,照射方法同对照组,每4周为1个周期,至少连用6个周期。以放疗结束时及结束后6个月的疼痛缓解率及血钙下降率作为评价标准。结果:治疗组疼痛缓解率和血钙下降率与对照组比较无明显差异;结束6个月后治疗组疼痛缓解率和血钙下降率均高于对照组(P<0.05)结论:帕米膦酸二钠(博宁)联合放疗可显著缓解骨转移引起的疼痛,降低高血钙,临床应用方便,患者耐受性好。Objective： To evaluate the effect of disodium pamidronate （Bolin） combined with radiotherapy in treatment of bone metastatic caner. Methods ：In control group ,30 patients received radiotherapy only. For all 64 patients, the radio - dose were DT 30GY/3GY/10f. In treatment group,34 patints with ostelytic metastasis diseases Bolin 90 mg dissolved in 0.9% NS and given by infusion for 4 - 6 hours. All patiens received radiotherapy. Bolin were adiministraeted every 4 weeks for 6 cycles. Results：There were no statistically differences in hypercalcermia level reduce and in pain release between the two groups. After 6 months, treatment group was superior to control group in the serum calcermia level reduce and pain release （ P 〈 0.05 ）, the treatment was well tolerated by patients. Conclusion： Treatment with 90mg of bolin every 4 weeks 6 cycles in addition to RT significantly reduces hypercacemia and pain from osteolytic metastases. The drug is conveniently used and well tolerated.

关 键 词：骨转移癌 帕米膦酸二钠(博宁) 放射治疗 高血钙 

分 类 号：R730.55[医药卫生—肿瘤]