高氧液治疗脑弥漫性轴索损伤患者的疗效评定  

EFFECT OF TREATMENT WITH HYPEROXIC LIQUID ON PATIENTS WITH DIFFUSE AXONAL INJURY

作　　者：刘小芬[1] 陈伟强[1] 郭静芳[1] 

机构地区：[1]汕头大学医学院第一附属医院,汕头515041

出　　处：《现代预防医学》2008年第16期3202-3204,共3页Modern Preventive Medicine

基　　金：汕头市重点科技攻关项目(汕府科[2006]82号)

摘　　要：[目的]探讨早期静脉输注高氧液对脑弥漫性轴索损伤的治疗疗效。[方法]纳入我院2000年1月～2007年1月住院的脑弥漫性轴索损伤病人162例,随机分为早期静脉输注高氧液组(84例)和对照组(78例),于治疗前后行神经元特异性烯醇化酶含量(NSE)的测定,同时评定格拉斯哥昏迷评分(GCS)的变化。[结果]经高氧液治疗,治疗组NSE明显降低,而GCS评分在治疗后20d、30d较对照组明显增加,与对照组相比有统计学差异(P﹤0.01)。[结论]早期静脉氧疗可显著减轻脑组织的病损程度,降低死亡率。[Objective] To explore the effect of the early treatment with hyperoxic liquid on patients with diffuse axonal injury （DAI）. [Methods] A total of 162 inpatients with DAI in out hospital form 2000 to 2005 were randomly divided into two groups, including the treatment group early treated with hyperoxic liquid and the control group treated with routine therapy. The myelin basic protein （NSE） were determined, Glasgow coma scales （GCS） were analyzed in both groups. [ Results] After treatment with hyperoxic liquid, the NSE in treatment group significantly decreased, while GCS were significantly improved after treatment for 20 or 30 days, which showed significant difference compared with the control group （P 〈 0.01 ）. [Collusion] Early treatment with hyperoxic liquid can alleviate the brain damage and decrease the mortality.

关 键 词：颅脑外伤 轴索损伤 

分 类 号：R741[医药卫生—神经病学与精神病学]