核因子-κB与脑膜瘤细胞增殖的关系  

RELATIONSHIP OF NUCLEAR FACTOR-κB WITH PROLIFERATION OF MENINGIOMA CELL

作　　者：夏祥国[1] 刘增进[1] 王丹 李新军[3] 陈礼刚 

机构地区：[1]泸州医学院附属医院神经外科,泸州646000 [2]辽宁省瓦房店市中心医院神经外科 [3]四川省德阳市人民医院神经外科

出　　处：《现代预防医学》2008年第16期3208-3210,3213,共4页Modern Preventive Medicine

摘　　要：[目的]探讨核因子-κB(NF-κB)在脑膜瘤的表达及其与脑膜瘤细胞增殖的关系。[方法]采用免疫组化SP法测定50例脑膜瘤组织、10例正常硬脑膜组织中NF-κBp65和增殖细胞核抗原(Proliferatingcellnuclearanti-gen,PCNA)的表达水平。[结果]正常硬脑膜组织中NF-κBp65无表达,脑膜瘤组织中NF-κBp65有不同程度的表达,两者之间的差异有统计学意义(P﹤0.05)。各型脑膜瘤之间NF-κB的表达差异有统计学意义(P﹤0.05)。NF-κB与PCNA在脑膜瘤组织中表达呈正相关(r=0.4524,P=0.001﹤0.05)。[结论]NF-κB在脑膜瘤组织中存在过度表达,可能与脑膜瘤的发生、增殖及对放疗、化疗不敏感有关。对NF-κB在脑膜瘤的进一步深入研究,可能获得药物治疗脑膜瘤的有效途径。[Objective] To explore the expression of the nuclear factor-kB in human meningioma and its relationship with the proliferation of meningioma cell. [Mothods] The immunohistochemical method was conducted to0 detect the expression of NF-kBp65 and Proliferating cell nuclear anti-gen （PCNA） of 50 human meningiomas and 10 human common cerebral dura maters. [Results] There was no expression of NF-kBp65 in the control cerebral dura mater tissues. But there are different level expression of NF-kBp65 in the meningioma tissues. The expression between the normal dura and meningioma showed significant difference （P 〈 0.05）. Among the different types of mieningioma, the expression of NF-kBp65 showed significant different （P 〈 0.05）. The expression of NF-kBp65 in human meningiomas showed significant positive correlation with PCNA （r = 0.452 4, P = 0.001 〈 0.05）. [Conclusion] The expression of NF-kB showed overexpression in the meningiomas, which possible relates to the occurrence and proliferation of meningioma cell and insensitivity to radiotherapy and chemotherapy. Deeper research of NF-kB is warranted to find the effective method of dryg treatment for meninaioma.

关 键 词：脑膜瘤 核田子-kB 核因子-kBp65 核因子kB抑制因子 增殖细胞核抗原 

分 类 号：R739.91[医药卫生—肿瘤]