增殖抑制基因和VEGF蛋白表达与直肠癌的关系  

RELATIONSHIPS BETWEEN EXPRESSION OF HUMAN HYPERPLASIC SUPPRESS GENE,VASCULAR ENDOTHELIAL GROWTH FACTOR AND COLORECTAL CANCER

作　　者：艾建中[1] 周艳红[2] 姜广建[3] 

机构地区：[1]唐山市工人医院普外科,河北唐山063000 [2]唐山职业技术学院医学基础部 [3]华北煤炭医学院生命科学系

出　　处：《承德医学院学报》2008年第3期234-236,共3页Journal of Chengde Medical University

摘　　要：目的:探讨增殖抑制基因(HSG)和血管内皮生长因子(VEGF)在直肠癌中的表达及意义。方法:采用免疫组化染色法检测正常直肠粘膜、良性腺瘤及直肠癌组织HSG和VEGF的表达。结果:正常粘膜、良性腺瘤、直肠癌HSG的阳性表达率分别为94.2%、74.2%和50.9%,VEGF的阳性表达率分别为8.1%、12.9%和75.5%。与正常粘膜和良性腺瘤比较,直肠癌HSG的表达明显下降、VEGF的表达明显增加(P<0.05)。根据TNM分期,直肠癌Ⅲ、Ⅳ期HSG的阳性表达率为33.3%,明显低于Ⅰ、Ⅱ期(P<0.05);直肠癌Ⅲ、Ⅳ期VEGF的阳性表达率为93.9%,明显高于Ⅰ、Ⅱ期(P<0.01);直肠癌中HSG和VEGF的阳性表达呈明显负相关(r=-0.367,P<0.05)。结论:HSG和VEG的表达可能对直肠癌的发生、发展及预后判断有一定作用。Objective：To investigate the expression and significance of the human hyperplasic suppress gene （HSG） and vascular endothelial growth factor VEGF in colorectal cancer.Methods：Immunohistochemisty was used to observe the expression of HSG and VEGF in normal rectal mucous membrane,benign adenoma and colorectal cancer.Results：The positive rate of HSG and VEGF in normal rectal mucous membrane,benign adenoma and colorectal cancer were respectively 94.2%,74.2%,50.9% and 75.5%, 12.9%,8.1%.Compared with normal rectal mucous membrane and benign adenoma,the HSG expression in colorectal cancer obviously decreased,while the VEGF expression obviously increased （P 〈 0.05）.According to TNM stage,the expression of HSG in Ⅲ＋Ⅳ stage was 33.3%,which was significantly lower than Ⅰ＋Ⅱ stage （P 〈 0.05）;the expression of VEGF in Ⅲ＋Ⅳ stage was 93.9%,which was significantly higher than Ⅰ＋Ⅱ stage （P 〈 0.01）.In colorectal cancer,the expression of HSG had obviously negative relations with expression of VEGF （r=-0.367,P 〈 0.05）. Conclusions：The expression of HSG and VEGF may have relations with occurrence,development and prognosis of colorectal cancer.

关 键 词：HSG VEGF 免疫组织化学 直肠癌 良性腺瘤 正常粘膜 

分 类 号：R735.3[医药卫生—肿瘤]