应用组织芯片研究CD44v9 mRNA在乳腺癌中的表达及意义  

EXPRESSION AND SIGNIFICANCE OF CD44V9 MRNA IN BREAST CANCER WITH TISSUE CHIP

作　　者：任立群[1] 齐洁敏[1] 宫凤春[1] 

机构地区：[1]承德医学院病理学教研室,河北承德067000

出　　处：《承德医学院学报》2008年第3期238-240,共3页Journal of Chengde Medical University

摘　　要：目的:探讨CD44v9 mRNA在乳腺癌发生发展中的作用。方法:应用组织芯片结合原位杂交方法检测60例乳腺癌、20例乳腺良性病变和20例正常乳腺组织中CD44v9 mRNA的表达情况。结果:乳腺癌CD44v9 mRNA的表达明显高于乳腺良性病变和正常组织(P<0.05)。乳腺癌组织中CD44v9 mRNA的表达与淋巴结转移、远处转移具有显著相关性,但与组织病理分级、肿瘤大小、年龄等无关(P>0.05)。结论:CD44v9 mRNA在乳腺癌发生发展中起一定作用,与侵袭转移密切相关。Objective：To investigate the effects of CD44v9 mRNA in occurrence and development of breast cancer.Methods：Tissue chip and in situ hybridization were used to detect CD44v9 mRNA expression in 60 breast cancer tissues,20 cases benign lesions and 20 normal tissues.Results：The expression of CD44v9 mRNA in breast cancer was obviously higher than that in benign lesions and normal tissues （P 〈 0.05）.In breast cancer,the CD44v9 mRNA expression had obvious correlations with lymph node metastasis and distant metastasis （P 〈 0.05）;but had no relations with pathlological stage,size of tumor and age （P 〉 0,05）.Conclusions： CD44v9 mRNA may play a role in pathogenesis and metastasis of breast cancer,and has close relations with invasion and metastasis.

关 键 词：乳腺癌 CD44 组织芯片 原位杂交 

分 类 号：R737.9[医药卫生—肿瘤]