甲壳低聚糖硒的合成、表征及降血糖作用  

Preparation and Token of Selenium-Chitooligosaccharides and Its Lowering of Blood-glucose

作　　者：方敏[1] 王及科[1] 曹朝晖[2] 李邦良[2] 

机构地区：[1]长沙市卫生学校医学基础二教研室,湖南省长沙市410100 [2]南华大学生物化学与分子生物学教研室

出　　处：《医学理论与实践》2008年第8期874-876,共3页The Journal of Medical Theory and Practice

基　　金：湖南省教育厅课题(NO.4-02-JY-02C399)

摘　　要：目的:研究甲壳低聚糖硒的合成并初步探讨其降糖效果。方法:以甲壳低聚糖与亚硒酸反应络合成甲壳低聚糖硒,并对该络合物的稳定性及硒含量进行检测;以20μg.kg-1.d-1体重剂量硒的甲壳低聚糖硒灌胃,观察其对实验性糖尿病大鼠空腹血糖的影响。结果:甲壳低聚糖硒水溶液中不存在游离的硒离子,表明硒元素与甲壳低聚糖形成了稳定的配合物;甲壳低聚糖硒能显著降低糖尿病大鼠空腹血糖。结论:甲壳低聚糖与硒能形成稳定的配合物,并具有显著的降糖作用。Objective：To study the synthesis of Selenium-Chitooligosaccharides and hypoglycemic activity in experimental type 2 diabetic rats. Methods： Chitooligosaccharide and inferior selenium sour response will compose Selenium- Chitooligosaccharides. Then determine the complex＇s stabilities and content of selenium. Selenium- Chitooligosaccharides were given to rats at a dose of 20μg · kg^-1 · d^-1 （eg,for 10 weeks）, and the effect on glucose level of diabetic rats was observed. Results： Selenium-Chitooligosaccharides aqueous solution has not dissociated selenium, which indicates that selenium element and chitooligosaccharide form a steady complex. Selenium-Chitooligosaccharides decrease the levels of fasting glucose. Conclusion： This finding suggests that Chitooligosaccharide and selenium can form the steady cooperation complex, and the hypoglycemic effect of the complex is obviously.

关 键 词：甲壳低聚糖硒 表征 降血糖 

分 类 号：R977.15[医药卫生—药品] TQ460.31[医药卫生—药学]