非小细胞肺癌淋巴管生成与肿瘤增殖和转移的关系  

Relationship between Lymphangiogenesis of Primary Non-small Cell Lung Cancer and Tumor Proliferation and Metastasis

作　　者：陈寿松[1] 彭正银[1] 陈昕薇[1] 肖同浩[1] 梁励玮[1] 

机构地区：[1]广州军区武汉总医院病理科,武汉430070

出　　处：《华南国防医学杂志》2008年第4期18-20,共3页Military Medical Journal of South China

基　　金：湖北省卫生厅科研基金项目(JX2B46)

摘　　要：目的探讨非小细胞肺癌淋巴管生成与肿瘤增殖和转移的关系。方法免疫组化SP法检测89例非小细胞肺癌组织中血管内皮生长因子C(VEGF-C)、血管内皮生长因子受体3(VEGFR-3),PCNA的表达。结果VEGF-C、VEGFR-3和PCNA在NSCLC组织中均有不同程度表达;NSCLC中VEGFR-3阳性脉管数在淋巴结有转移组显著高于无淋巴结转移组。结论NSCLC中VEGF-C的表达与NSCLC中淋巴管的生成、肿瘤细胞增殖及淋巴管转移有关,是判断NSCLC患者预后的指标之一。Objective To investigate the relationship between lymphangiogenesis of primary non-small cell lung cancer and tumor proliferation and metastasis. Methods Expression of VEGF-C, VEGFR-3 and PCNA was detected by SP method in 89 NSCLC cases. Results VEGF-C, VEGFR-3 and PCNA expressed with different levels in NCSLC cases. The number of positive VEGFR-3 microvessels in lymphatic node with metastasis was significantly higher than that in lymphatic node without metastasis. Conclusion Expression of VEGF-C and VEGFR-3 can be utilized as the indicator of lymphangiogenesis and lymphatic metastasis in non-small cell lung cancer.

关 键 词：非小细胞肺癌 VEGF-C VEGFR-3淋巴管生成转移 

分 类 号：R734.2[医药卫生—肿瘤]