门静脉癌栓形成与肝癌干细胞转移的关系  

Correlation between formation of portal vein tumor thrombus and liver cancer stem cells metastasis

作　　者：胡华生(综述)[1] 石洁(综述)[1] 程树群(审校)[1] 

机构地区：[1]第二军医大学东方肝胆外科医院肿瘤综合治疗科,上海200438

出　　处：《国际肿瘤学杂志》2008年第7期527-530,共4页Journal of International Oncology

基　　金：上海市科委基础研究重点项目（07JC14066）;上海市教委“曙光学者”资助项目;上海市教育发展基金会晨光计划资助项目（2007CG48）

摘　　要：近期的干细胞研究提示门静脉癌栓（PVTT）可能与肝癌干细胞在门静脉微环境诱导下的定向转移有关，肝癌干细胞脱离原发病灶，外渗到细胞外基质，促进血管的生成或细胞内渗，从而进入循环系统，逃避宿主的防御机制，通过趋化作用迁移到特定的门静脉内皮黏附，归巢到特定的微环境，形成门静脉癌栓。Recent studies about stem cells show that the formation of portal vein tumor thrombus （PVTT） is closely relative to the metastasis of liver cancer stem cells induced by portal vein microenvironment. Liver cancer stem cells first detach from the primary tumor, extravasate to extracellular matrix, stimulate angiogenesis or intravasate and migrate through the systemic circulation, evade host defense mechanisms, migrate to specific blood vessel sites through chemo-taxis and attach to blood vessel wall, then extravasate through blood vessel and home to specific microenvironment and to form PVTT.

关 键 词：门静脉 肿瘤循环细胞 肿瘤干细胞 肿瘤转移 

分 类 号：R730.21[医药卫生—肿瘤] H730.231[医药卫生—临床医学]