CXCR4和血管内皮生长因子在胆管癌中的表达及其临床意义  

Expressions and clinical significance of CXCR4 and VEGF in human holangiocarcinoma

作　　者：霍胜军[1] 汤恢焕[1] 魏伟[1] 

机构地区：[1]中南大学湘雅医院普通外科,长沙市410008

出　　处：《实用医学杂志》2008年第14期2367-2369,共3页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:20335020)

摘　　要：目的:探讨CXCR4和血管内皮生长因子(VEGF)蛋白在肝外胆管癌中的表达相关性及其与胆管癌发展和预后的关系。方法:应用免疫组化技术SP法检测CXCR4和VEGF蛋白在35例胆管癌标本、10例正常胆管标本中的表达。结果:胆管癌组织中CXCR4的阳性表达率为54%(19/35),VEGF的阳性表达率为77%(27/35);在正常胆管组织中未检测到CXCR4和VEGF的表达。癌组织中CXCR4和VEGF蛋白的表达呈正相关(r=0.715,P<0.05)。CXCR4和VEGF蛋白表达与肿瘤转移与否、复发关系密切,但与患者的性别、年龄、肿瘤大小及分化无关。结论:CXCR4和VEGF在胆管癌中高表达,两者表达呈正相关;与胆管癌的转移和预后关系密切。Objective To explore the expressions of CXCR4 and VEGF proteins in cholangiocareinoma and their relationship with clinical pathological features and the prognosis. Methods Expression of CXCR4 and VEGF proteins were detected by SP immunohistochemical technique in 35 cases of extrahepatic cholangiocarcinoma, 10 nomal bile duct tissues. Results The positive rates of CXCR4 and VEGF proteins were 54% （19/35）and 77% （27/35）in extrahepatic cholangiocarcinoma, respectively. The expression of CXCR4 protein was significantly positively correlated with that of VEGF protein（P 〈 0.05） in cholangiocarcinoma. In contrast, no expression of CXCR4 and VEGF proteins was detected in 10 cases of nomal bile duct. The expression of CXCR4 and VEGF was closely related to metastasis and palindromia, but was not related to sex or age of the patients, tumor size or tumor differentiation. Conclusions There is a significant positive correlation between high expressions of CXCR4 and VEGF proteins in cholangiocareinoma. The high expressions of CXCR4 and VEGF proteins may be related to the metastasis and palindromia of extrahepatic cholangiocarcinoma.

关 键 词：胆管肿瘤 受体 CXCR4 血管内皮生长因子类 预后 

分 类 号：R735.8[医药卫生—肿瘤]