直肠癌患者血浆D-二聚体和纤维蛋白原水平的检测及临床价值  

Assay and clinical significance of plasma D-dimer and fibrinogen in patients with rectal cancer

作　　者：高阳[1] 庄竟[1] 张勇超[1] 刘永刚[1] 

机构地区：[1]河南省肿瘤医院普外科,郑州450008

出　　处：《中国肿瘤临床与康复》2008年第4期322-324,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨直肠癌患者血浆D-二聚体(D-dimer)和纤维蛋白原(Fib)水平变化与直肠癌疗效、预后的关系。方法取250例直肠癌患者和40例对照组(健康体检者)的静脉血,应用全自动血凝仪测定,血浆D-二聚体含量采用乳胶凝集半定量法测定,血浆纤维蛋白原含量采用Clauss法测定。结果250例直肠癌患者中,直肠癌初治组、难治转移组、治疗缓解组的血浆D-二聚体和纤维蛋白原水平明显升高,与对照组比较差别有显著性;治疗缓解组的血浆D-二聚体、纤维蛋白原水平较初治组及难治转移组有明显下降。结论血浆D-二聚体和纤维蛋白原水平变化与直肠癌的病情严重程度及预后有明显相关性,可作为直肠癌的辅助诊断及预后判断的一项早期实验室参考指标。Objective To investigate the relation of plasma level of D-dimer and fibrinogen with therapeutic efficacy and prognosis of rectal cancer. Methods 250 patients suffering from rectal cancer and 40 normal adult were enrolled. For each patient, plasma D-dimer and fibrinogen were determined by automatic coagulation analyzer. Plasma D-dimer was examined by latex agglutination test （LAT）. Plasma fibrinogen was measured by Clauss test. Results The D-dimer and fibrinogen levels were increased in the primary therapy group, refractory metastasis group and relief group compared with those in the normal adult group. The D-dimer and fibrinogen levels were decreased in the relief group compared with those in primary therapy group and the repractory metastasis group. Conclusions Plasma D-dimer and fibrinogen levels were closely related with the progression of rectal cancer patients＇ condition and prognosis. Detection of D-dimer and fibrinogen may play an important role not only in the laboratory diagnosis of rectal cancer, but also in the evaluation of prognosis.

关 键 词：结直肠肿瘤 D-二聚体 纤维蛋白原 预后 

分 类 号：R735.3[医药卫生—肿瘤] R730.43[医药卫生—临床医学]