食管鳞癌survivin表达与放化疗近期疗效的关系  

Relationship between survivin expression and chemoradiotherapy response in esophageal squamous cell carcinoma

作　　者：黄伟钊[1] 刘孟忠[2] 胡祎[3] 杨弘[3] 郑斌[3] 王耿[3] 罗孔嘉[3] 文静[3] 傅剑华[3] 

机构地区：[1]中山大学附属肿瘤医院胸外科 [2]中山大学附属肿瘤医院放疗科,广东省广州市510089 [3]华南肿瘤学实验室,中山大学附属肿瘤医院胸外科,广东省广州市510089

出　　处：《世界华人消化杂志》2008年第20期2295-2299,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨survivin表达情况与食管鳞癌原发灶的放化疗反应的关系.方法:用免疫组化法检测112例食管鳞癌中survivin的表达情况,回顾性分析胞质和胞核的survivin表达与放化疗近期疗效及放化疗后降期情况的关系.结果:survivin的表达可见于肿瘤细胞的胞质或/和胞核内,其中胞核表达率为67.8%,胞质表达率为65.2%;胞质survivin表达与近期疗效无明显关系,而胞核survivin阴性者放化疗的中期有效率明显高于阳性者(80.6%vs46.1%,P=0.026).术前放化疗组中,核survivin阳性者与阴性者放化疗后降期的比例分别为7/17和4/4.结论:检测核survivin的表达情况可能作为预测食管鳞癌对放化疗疗效的有效参考指标.AIM： To investigate the relationship between survivin expression and the chemoradiotherapy （CRT） response in esophageal squamous cell carcinoma （ESCC）. METHODS： The expression of survivin in 112 cases of ESCC tissues were detected using im- munohistochemistry （IHC）. Relation between survivin expression （including nucleus and cy- toplasm expression） and short-term response as well as its relationship with downstage rate of CRT were analyzed retrospectively. RESULTS： Survivin expression was noted in ESCC cytoplasm and nucleus with 65.2% and 67.8% expression rates respectively. Survivin expressed in cytoplasm was not correlated to short-term response, but the response of patients with nuclear survivin expression was signifi- cantly lower than that with nuclear negative expression （46.1% vs 80.6%, P=0.026）. In neoad- juvant CRT group, downstage rates of patients with positive and negative nuclear survivin were 7/17 and 4/4 respectively. CONCLUSION： Assessment of nuclear survivin could provide additional information to identify ESCC patients with poor chances of response to CRT and candidates for more individualized treatment.

关 键 词：食管癌 SURVIVIN 放化疗 预后 

分 类 号：R735.1[医药卫生—肿瘤]