儿童少年行为问题中的遗传-家庭亲密度交互作用研究  

A study on gene and family cohesion interplay in behavior problems

作　　者：金敏[1] 杨彦春[1] 张岚[1] 毕建强[1] 徐佳军[1] 

机构地区：[1]四川大学华西医院心理卫生中心

出　　处：《四川精神卫生》2008年第3期129-131,共3页Sichuan Mental Health

基　　金：美国弗吉尼亚州大学精神及行为遗传研究所Kenneth Kendler教授为本课题提供技术指导和资金支持

摘　　要：目的研究儿童少年行为问题的影响因素中,遗传因素与家庭亲密度之间是否存在交互作用。方法分别采用Achenbach儿童行为量表和家庭环境量表中文版亲密度分量表对多级随机抽样的64对双生子进行评定,并分析遗传因素与家庭亲密度之间的关系。结果双生子的家庭亲密度为(6.66±1.91),低于中国常模(P<0.001)。不同卵性双生子家庭亲密度的差异无统计学意义(P>0.05);在低亲密度及高亲密度家庭环境中,儿童少年的行为问题遗传度分别为0.88和0.75,前者的遗传度高于后者。结论双生子家庭亲密度低于非双生子家庭;儿童少年行为问题的遗传因素与家庭亲密度之间可能存在交互作用。Objective To test whether gene and family cohesion interplay in behavior problems. Methods A total of 64 twin pairs aged 10 - 16 years participated in this study after multi - stage sampling. The child behavior checklist（CBCL） rated by twin parents was used to assess behavior problems and the cohesion subscale of the family environment scale（ FES - CV） was used to assess family cohesion. Gene - family cohesion interaction analyse was conducted. Results The average of twin family cohesion was （6. 66 ± 1.91 ） ,lower than Chinese norm （P 〈 0. 001 ）. No difference was found in family cohesion between different zygosity（P 〉0. 05）. For behavior problems of children and adolescents,genetic influences estimates were 0. 88 and 0. 75 respectively in family environment of low and high level cohesion, which showed heritability of behavior problems in low cohesive family environment exceeded that in high cohesive family environment. Conclusions The family cohesion of twins was lower than that of nontwins. For behavior problems of children and adolescents, genetic factors and family cohesion maybe interacted.

关 键 词：儿童 少年 行为 问题遗传 环境交互作用 

分 类 号：R749.3[医药卫生—神经病学与精神病学]