齐哌西酮与氯丙嗪治疗女性精神分裂症患者的疗效比较  

Therapeutic effect and security of ziprasidone in the female patients with schizophrenia

作　　者：张玉花[1] 韩鹏[1] 申连成[1] 宁艳玲[1] 

机构地区：[1]山东省济宁市精神病防治院,272051

出　　处：《四川精神卫生》2008年第3期149-152,共4页Sichuan Mental Health

摘　　要：目的探讨齐哌西酮治疗女性精神分裂症患者的疗效及安全性。方法将女性精神分裂症患者随机分为齐哌西酮组和氯丙嗪组各50例,共治疗8周。分别采用阳性与阴性症状量表(PANSS)、不良反应量表(TESS)、生活质量量表(WHOQOL-100)评定疗效、不良反应和生活质量,同时检测体重、血糖及催乳素。结果齐哌西酮与氯丙嗪的总体疗效相当(P>0.05);氯丙嗪较齐哌西酮引起的锥体外系不良反应及抗胆碱能作用发生率高(P<0.05);而齐哌西酮对血清催乳素、血糖、体重影响则较小(P<0.05);齐哌西酮组WHOQOL-100各项均明显改善(P<0.05),氯丙嗪组则有改善,但无显著性差异(P>0.05);两组比较有显著性差异(P<0.05)。结论齐哌西酮与氯丙嗪疗效相当,不良反应小,可明显改善患者生活质量。Objective To explore the therapeutic effect and security of ziprasidone in the female patients with schizophrenia.. Methods 100 female schizophrenia patients were assigned to ziprasidone group and chlorpromazine group for 8 weeks. PANSS,TESS and WHO QOL- 100 were applied to messure therapeutic effects,adverse effects and quality of life. Results The total therapeutic effects of ziprasidone were equal to chlorpromazine （P 〉 0. 05 ）. The incidece rate of EPS and chohnergic adverse effect of chlorpromazine were higher than ziprasidone （P 〈 0. 05 ）. The effects of ziprasidone to PRL, BS, and weight were smaller than chlorpromazine （ P 〈 0. 05 ）. The ziprasidone group were improved more significantly than chlorpromazine group in every domain of WHO QOL - 100 （P 〈 0.05 ）. Conclusion The total therapeutic effects of ziprasidone were equal to chlorpromazine and the ziprasidone had less adverse effects and improved higher quality of life than chlorpromazine.

关 键 词：齐哌西酮 氯丙嗪 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]