消化性溃疡患者胃排空与血浆胃肠激素的变化  

Gastric emptying and plasma levels of gastrointestinal hormones in patients with peptic ulcer

作　　者：陈建[1] 李君曼[1] 李学会[1] 郝洪升[1] 付淑花[1] 

机构地区：[1]山东医科大学附属医院消化内科

出　　处：《新消化病学杂志》1997年第11期717-718,共2页

基　　金：山东省卫生厅科研基金

摘　　要：目的探讨胃肠激素及胃排空的变化在消化性溃疡发病机制中的作用．方法胃溃疡（ＧＵ）３０例，男１８例，女１２例，年龄２５岁～６６岁，平均５０９５岁；十二指肠溃疡（ＤＵ）２９例，男１８例，女１１例，年龄２５岁～６２岁，平均４００５岁；健康人１２例为对照组，男９例，女３例，年龄２５岁～６３岁，平均４６５岁．采用ＲＩＡ法测定空腹血浆生长抑素（ＳＳ）、血管活性肠肽（ＶＩＰ）和Ｐ物质（ＳＰ）水平，同时应用放射性核素法检测胃排空功能．结果ＧＵ患者胃排空（ｍｉｎ）明显迟缓（６５９±１４８ｖｓ５３３±４３，Ｐ＜００１），空腹血浆ＶＩＰ水平（ｎｇ／Ｌ）较对照组明显升高（３７５±１０７ｖｓ１８４±５９，Ｐ＜００５），且与胃半排空时间（ＧＥＴ１／２）呈显著性正相关（ｒ＝０５５，Ｐ＜００１）；ＳＳ和ＳＰ水平与对照组无明显变化（Ｐ＞００５）．ＤＵ患者胃排空明显亢进（４１７±１０２ｖｓ５３３±４３，Ｐ＜００１），ＳＳ水平（ｎｇ／Ｌ）显著降低（６４±２５ｖｓ１１９±３４，Ｐ＜００１），并与ＧＥＴ１／２呈显著性正相关（ｒ＝０５６，Ｐ＜００１）；ＳＰ水平（ｎｇ／Ｌ）显著升高（５４４±１２?IM To study the plasma level of gastrointestinal hormones and gastric emptying in patients with peptic ulcer. METHODS Thirty patients with gastric ulcer (GU), and 29 duodenal ulcer (DU) and 12 controls were studied. Plasma levels of SS, VIP and SP were measured by radioimmunoassay, and gastric emptying half time (GET1/2) was determined with TC99mresin solid meal method. RESULTS GET1/2(min) was significantly longer in GU than that in controls (659±148 vs 533±43, P<001) and plasma VIP levels (ng/L) were significantly higher than in controls (375±107 vs 184±59, P<005). There was a significant positive correlation between GET1/2 and plasma VIP levels (r=055,P<001). No significant changes were found in SS and SP in GU compared with controls (P>005). GET1/2 in DU was markedly shorter than the control group (417±102 vs 533±43,　P<001), and plasma SS levels (ng/L) significantly lower than those in controls (64±25 vs 119±34,P<001), there was a significant positive correlation between GET1/2 and SS levels (r=056,P<001). Plasma SP levels (ng/L) in DU were significantly higher than the controls (544±127 vs 416±58,P<001),there was a significant negative correlation between GET1/2 and SP levels (r=-068,P<001). No significant difference was found in the plasma VIP levels between DU and controls (P>005).CONCLUSION VIP elevation may contribute to the GET1/2 delay and the occurrence of GU. The increased SP and lowered SS may play important roles in the GET1/2 acceleration and the pathogensis of DU.

关 键 词：消化性溃疡 胃排空 胃肠激素类 血液 

分 类 号：R573.102[医药卫生—消化系统]