大鼠非酒精性脂肪性肝病超声与病理变化的相关性研究  

Analysis of High Frequency Ultrasound and Pathological Features of Nonalcoholic Fatty Liver Disease in Rats

作　　者：吴静[1] 郑浩[1] 江瑛[2] 许晴[3] 史小琳[3] 张倩[1] 王萍[1] 张华[3] 

机构地区：[1]首都医科大学宣武医院超声诊断科,北京市100053 [2]首都医科大学病理生理系 [3]首都医科大学组胚系

出　　处：《中国超声医学杂志》2008年第8期688-691,共4页Chinese Journal of Ultrasound in Medicine

基　　金：北京市教委科技发展面上项目(No.KM200710025003);首都医科大学基础-临床合作基金(No.2006JL12)

摘　　要：目的研究大鼠非酒精性脂肪性肝病超声与病理变化的相关性。方法将64只大鼠随机分为对照组（24只）和模型组（40只），模型组动物通过高脂饮食建立非酒精性脂肪性肝病大鼠模型，分别于8、12、16、22周进行超高频超声及病理检查，测量相关指标。结果超声检查8周模型组声像图表现：肝脏增大，实质回声较正常肝脏回声细密增强，后方组织明显衰减，肝内管系组织显示不清；12～22周逐渐加重，肝缘圆钝。病理表现：8周模型组为单纯性脂肪肝，而12～22周模型组均为中-重度脂肪肝，从脂肪性肝炎进展到脂肪性肝纤维化。组间比较具有显著性差异（P〈0．05）。结论超高频小动物超声仪检查不同时期大鼠非酒精性脂肪性肝病与病理结果相一致，对诊断有具有较高价值。Objective To analyze the relationship between high frequency ultrasound diagnosis and pathological manifestation of nonalcoholic fatty liver disease （NAFLD） in rats. Methods A total of 64 SD rats were randomly divided into normal control （24）and experimental groups （40）. The experimental groups were fed with highfat diet. Ultrasound and pathological evaluation were detected in 8, 12, 16 and 22 weeks, respectively. Results Fat degeneration commenced after 8 weeks of high-fat diet. The liver was enlarged the edge of which became dull. The echoes in the liver were enhanced, and the vessels became indistinct. Those phenomena were more marked after 12 weeks. In pathological images, The simple fatty livers were observed in the model group at 8 week. From 12 weeks to 22 weeks, the liver gradually progressed from nonalcoholic steatohepatitis （NASH） to liver fibrosis. There were significant differences of both ultrasound and pathological features between the control and experimental group （P〈 0.05）.Conclusions High frequency ultrasound manifestations is consistant with pathological changes in NAFLD rats, which may serve as a reliable non-invasive technique for diagnosing fatty liver disease in clinical.

关 键 词：非酒精性脂肪性肝病 大鼠 超高频超声 

分 类 号：R575.5[医药卫生—消化系统] R445.1[医药卫生—内科学]