胸腔置管引流并灌注白细胞介素Ⅱ联合顺铂治疗肺癌恶性胸腔积液疗效观察  

Thoracostomy closed drainage combined instillation of interleukin-2 and cisplatin in treatment of malignant pleural effusion

作　　者：蔡宇星 郝毅[2] 

机构地区：[1]陕西省宝鸡市中心医院呼吸内科,721000 [2]陕西省宝鸡市妇幼保健院

出　　处：《齐齐哈尔医学院学报》2008年第13期1537-1538,共2页Journal of Qiqihar Medical University

摘　　要：目的观察胸腔置管引流并灌注白细胞介素Ⅱ联合顺铂（PPD）治疗肺癌伴恶性胸腔积液的近期疗效和毒副反应。方法65例肺癌伴恶性胸腔积液患者，先用深圳市益心达医学新技术有限公司生产的一次性双腔中心静脉导管进行胸腔置管和闭式引流胸液，充分引流后给予胸腔内注药。观察组（n=25例）胸腔灌注顺铂（PPD）联合白细胞介素Ⅱ；对照组1（n=20例）胸腔灌注单用顺铂（PPD）；对照组2（n=20例）胸腔灌注单用白细胞介素Ⅱ。顺铂每次注入40-60mg，白细胞介素Ⅱ每次注入40-60万U，1-2次／周，连续注射2、3周，1个月后观察两组的疗效及不良反应。结果白细胞介素Ⅱ联合顺铂对恶性胸腔积液的有效率为84.0％，明显优于单用顺铂组60.0％及单用白细胞介素Ⅱ组50.0％（P〈0.05）。结论胸腔置管引流并灌注白细胞介素Ⅱ联合顺铂治疗肺癌恶性胸腔积液，疗效肯定，是控制恶性胸腔积液的有效方法。Objective To evaluate the effect and adverse reactions of IL-2 and cisplatin（PPD） in the treatment of the patients with lung cancer combining malignant pleura effusion by thoracic cavity perfusion drainage. Methods Effusion were applied with the double cavity central venous catheters,and all patients were taken the closed thoracic drainage and divided into three groups. The patients in research group （n=25） were treated by associated injection of IL-2 and PPD, and those in control group I （n = 20） were treated by independent injection of PPD, and those in control group Ⅱ（n= 20） were treated by independent injection of IL-2. IL-2 at a dose of 4-6×10^5u was injected and that of PPD was 40-60 mg every time. The doses were given 1-2 times every week,for 2-3 weeks. The therapeutic effect and adverse reactions were observed after one month. Results The effect of the research group evidently excelled the control groups （P〈0.05）. Conclusions After draining completely the pleural effusion,the associated injection of IL-2 and PPD is more effective for the treatment of malignant pleural effusion.

关 键 词：恶性胸腔积液 胸腔闭式引流 白细胞介素Ⅱ 顺铂 

分 类 号：R735.705[医药卫生—肿瘤] R561.3[医药卫生—临床医学]