NDRG2： a Myc-repressed gene involved in cancer and cell stress  

作　　者：Libo Yao Jian Zhang Xuewu Liu 

机构地区：[1]The Institute of Molecular Biology and the State Key Laboratory of Cancer Biology, Fourth Military Medical University. Xi'an 710032,China

出　　处：《Acta Biochimica et Biophysica Sinica》2008年第7期625-635,共11页生物化学与生物物理学报（英文版）

基　　金：This work was supported by grants from the Changjiang Scholars and Innovative Research Team in Unixersities of China （No. PCSIRT0459） and the National Natural Science Foundation of China CNos. 30228012. 30370315, 30570676. 30670452. 30700416 and 06G0921

摘　　要：As a master switch for cell proliferation and differentiation, Myc exerts its biological functions mainly through transcriptional regulation of its target genes, which are involved in cells＇ interaction and communication with their external environment. The N-Myc downstream-regulated gene （NDRG ） family is composed of NDRG1, NDRG2, NDRG3 and NDRG4, which are important in cell proliferation and differentiation. This review summarizes the recent studies on the structure, tissue distribution and functions of NDRG2 that try to show its significance in studying cancer and its therapeutic potential.As a master switch for cell proliferation and differentiation, Myc exerts its biological functions mainly through transcriptional regulation of its target genes, which are involved in cells＇ interaction and communication with their external environment. The N-Myc downstream-regulated gene （NDRG ） family is composed of NDRG1, NDRG2, NDRG3 and NDRG4, which are important in cell proliferation and differentiation. This review summarizes the recent studies on the structure, tissue distribution and functions of NDRG2 that try to show its significance in studying cancer and its therapeutic potential.

关 键 词：N-Myc downstream-regulated gene tumor suppressor cell stress 

分 类 号：R394[医药卫生—医学遗传学]