慢性肝炎不同证型与细胞因子PDGF TGF-β相关性研究  

Correlation Study on TCM′s Syndrome Differentiation Typing with Cytokines PDGF TGF-β in Chronic Hepatitis

作　　者：楼孝惠 夏小芳[1] 王际云[1] 吴建[1] 屠建国[1] 徐伟[1] 

机构地区：[1]杭州第四医院,浙江杭州310002

出　　处：《中华中医药学刊》2008年第8期1776-1778,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：杭州市科技局资助项目(2004433Q25);杭州市卫生局科研基金资助项目(2003A016)

摘　　要：目的:研究和探讨慢性肝炎患者血清PDGF、TGF-β含量与慢性肝炎不同证型之间的关系。方法:根据辨证设慢性肝炎肝郁脾虚、湿热中阻、瘀血阻络3组各30例和正常对照组30例,采用酶联免疫吸附法(ELISA)检测不同证型慢性肝病患者血清PDGF、TGF-β的含量。结果:肝郁脾虚等3组PDGF、TGF-β含量阳性率均高于正常对照组,差异有显著性;瘀血阻络证组高于肝郁脾虚、湿热中阻,差异有显著性;定量水平结果亦与其相符;肝炎程度不同,其PDGF、TGF-β水平也不同,差异有显著性。结论:慢性肝炎不同证型肝纤维化程度不同,与PDGF、TGF-β水平有较强的关联。Objective：To study the relationship between TCM＇s syndrome differentiation typing and serum levels of PDGF and TGF -β in chronic hepatitis. Methods ： 90patients suffering from chronic hepatitis were divided into 3 groups according to the TCM＇s typing, including liver depression and spleen deficiency syndrome group （30cases）, middle energizer dampness - heat syndrome group （ 30cases ） and blood - stasis obstruction syndrome group （ 30cases ）. And control group （30 healthy persons ）was established. The serum concentration of PDGF and TGF -β of the 120 persons was detected by ELISA. Results ： The serum concentration of PDGF and TGF -β in the patients was higher than that in healthy persons. The serum concentration of PDGF and TGF - [3 in blood - stasis obstruction syndrome group was higher than that in the group of liver depression and spleen deficiency syndrome and middle energizer dampness - heat syndrome. The quantitative level was accordant with above qualitative level. The serum levels of PDGF and TGF -β was different in various degree hepatitis. The difference was significant in all above situation. Conclusion ：Various TCM＇s syndrome of chronic hepatitis are different not only in macroscopic diagnostic indexes but also in microcosmic indicator. It is strongly relative with the PDGF and TGF -β.

关 键 词：慢性肝病 证型 PDGF TGF-Β 

分 类 号：R575.1[医药卫生—消化系统]