血清CEA、CA199、CA724联合黏膜端粒酶检测对大肠癌诊断及预后评价的价值  

Study on the Clinical Application of Combined Measurement of Serum CEA,CA199,CA724 and Mucosal Telomerase for the Diagnosis and Prognostic Evaluation with Carcinoma of Large Intestine

作　　者：毕超[1] 肖创情[1] 黄修海[1] 张一帆[1] 刘祥[1] 

机构地区：[1]解放军第163医院,湖南长沙410003

出　　处：《医学临床研究》2008年第8期1414-1416,共3页Journal of Clinical Research

摘　　要：【目的】探讨血清CEA、CA199、CA724和黏膜端粒酶单项或多项联检对大肠癌的诊断及预后评价意义。【方法】用电化学发光法检测82例大肠癌患者和42例良性病变及38例健康人血清中的CEA、CA199、CA724和黏膜端粒酶含量并分析敏感性、特异性。【结果】大肠癌血清CEA、CA199、CA724和黏膜端粒酶含量显著高于正常健康对照组及良性病变组(P<0.05),联合检测其敏感性和特异性明显高于单项检测(P<0.05)。Dukes分期超高,血清CEA、CA199、CA724和黏膜端粒酶的阳性率依次增高,CA724和黏膜端粒酶和病理分型相关,分化程度越低,阳性率越高。【结论】血清CEA、CA199、CA724和黏膜端粒酶可用于大肠癌的早期诊断、病情判断,联合检测更具临床意义。[Objective]To explore the clinical significance of serum CEA, CA199, CA724 and mucosal telomerase levels for the diagnosis and prognosis in patients with carcinoma of large intestine. [Methods] Altogether 82 patients with carcinoma of large intestine, 42 patients with benign lesion, 38 healthy subjects served as controls were included in this study. Serum CEA ,CA199, CA724 and mueosal telomerase were measured by electrochemiluminescence immunoassay,and their sensitivity and specificity were analyzed. [Results]The serum CEA ,CA199 ,CA724 and mucosal telomerase levels in patients with carcinoma of large intestine were significantly higher than those in normal subjects and patients with benign lesion （ P 〈0.05）. The sensitivity and specificity of combined measurement were significantly higher than those in single detection. Serum levels and diagnostic sensitivity of all these four markers were significantly successively increased as the patholological dukes grading of the lesion. [Conclusion] Determination of serum CEA, CA199, CA724 and mucosal telomerase levels are the valid tumor markers for diagnosis and evaluation of patients with carcinoma of large Intestine. The clinical value of combined detection is better.

关 键 词：结肠直肠肿瘤/血液 癌胚抗原/血液 抗原 肿瘤相关 碳水化合物/血液 端粒 末端转移酶/血液 预后 

分 类 号：R735.35[医药卫生—肿瘤]