NF-κB在造血系统肿瘤中作用的研究进展  

Role of NF-κB in Hematopoietic Malignancies——Review

作　　者：陈聪[1] 陈莉[1] 

机构地区：[1]第二军医大学长海医院血液科,上海200433

出　　处：《中国实验血液学杂志》2008年第4期954-959,共6页Journal of Experimental Hematology

基　　金：上海市卫生局科技发展基金;编号034116

摘　　要：核转录因子κB(nuclear transcription factorκB,NF-κB)是一类关键性的核转录因子,通常以同源或异源二聚体非活性形式存在于几乎所有类型细胞的胞质,其与免疫细胞的活化,T,B淋巴细胞的发育,应激性反应,细胞凋亡等多种细胞活动有关。近年研究显示,NF-κB与造血系统肿瘤如白血病、淋巴瘤和多发性骨髓瘤的发生关系密切,本文就国外近期有关NF-κB在造血系统肿瘤中的研究进展作一综述,其中论述的问题包括有NF-κB家族及其活化,NF-κB活化对细胞凋亡的影响,髓系白血病NF-κB的活化及其机制,淋巴细胞白血病NF-κB的活化及其机制,淋巴瘤NF-κB的活化及其机制,多发性骨髓瘤NF-κB的活化及其机制和NF-κB抑制在造血系统肿瘤中的应用等。NF-κB is a kind of important nuclear factors which are relative to lots of cellular activities such as activation of immunocyte, development of T and B lymphocyte, stress reaction, cell apoptosis and so on. NF-κB exists in almost all types of cytoplasm in the unreactive form of heterodimer or homodimer. Recent studies have shown that there is close relationship between NF-κB and pathogenesis of hematopoietic malignancies such as leukemia, lymphoma and multiple myeloma. In this review, the advances of studies on the role of NF-κB in hematopoietic malignancies were summarized, including subumits of NF-KB and its activity, activity of NF-KB and its effect on apoptosis, activity of NF-κB in AML cells and its mechanism, activity of NF-κB in ATL cells and its mechanism, activity of NF-κB in lymphoma and its mechanism, activity of NF-κB in multiple myeloma cells and its mechanism, application of NF-κB suppression in hematopoietic malignancies and so on.

关 键 词：造血系统肿瘤 NF—κB 细胞凋亡 

分 类 号：R733[医药卫生—肿瘤]