Risk factors of thrombosis in abdominal veins  

作　　者：Amit Kumar Dutta Ashok Chacko Biju George Joseph Anjilivelil Joseph Sukesh Chandran Nair Vikram Mathews 

机构地区：[1]Department of Gastrointestinal Sciences,Christian Medical College & Hospital,Vellore 632 004,India [2]Department of Clinical Pathology,Christian Medical College & Hospital,Vellore 632 004,India [3]Department of Hematology,Christian Medical College & Hospital,Vellore 632 004,India

出　　处：《World Journal of Gastroenterology》2008年第28期4518-4522,共5页世界胃肠病学杂志（英文版）

摘　　要：AIM: To estimate the prevalence of inherited and acquired thrombophilic risk factors in patients with abdominal venous thrombosis and to compare the risk factor profiles between Budd-Chiari syndromes (BCS) and splanchnic vein thrombosis (SVT). METHODS: In this retrospective study, 36 patients with abdominal venous thrombosis were studied. The patients were divided into Budd-Chiari group (hepatic vein, IVC thrombosis) and splanchnic venous thrombosis group (portal, splenic, superior mesenteric veins) based on the veins involved. Hereditary and acquired thrombophilic risk factors were evaluated in all patients. RESULTS: Twenty patients had SVT, 14 had BCS, and 2 had mixed venous thrombosis. Ten patients (28%) had hereditary and 10 patients (28%) acquired thrombophilic risk factors. The acquired risk factors were significantly more common in the SVT group (SVT vs BCS: 45% vs 7%, χ2 = 5.7, P = 0.02) while hereditary risk factors did not show significant differences between the two groups (SVT vs BCS: 25% vs 36%, χ2 = 0.46, P = 0.7). Multiple risk factors were present in one (7%) patient with BCS and in 3 patients (15%) with SVT. No risk factors were identified in 57% of patients with BCS and in 45% of patients with SVT. CONCLUSION: Hereditary and acquired risk factors play an important role in the etiopathogenesis of abdominal venous thrombosis. Acquired risk factorsare significantly more common in SVT patients while hereditary factors are similar in both groups.AIM： To estimate the prevalence of inherited and acquired thrombophilic risk factors in patients with abdominal venous thrombosis and to compare the risk factor profiles between Budd-Chiari syndromes （BCS） and splanchnic vein thrombosis （SVT）. METHODS： In this retrospective study, 36 patients with abdominal venous thrombosis were studied. The patients were divided into Budd-Chiari group （hepatic vein, IVC thrombosis） and splanchnic venous thrombosis group （portal, splenic, superior mesenteric veins） based on the veins involved. Hereditary and acquired thrombophilic risk factors were evaluated in all patients. RESULTS： Twenty patients had SVT, 14 had BCS, and 2 had mixed venous thrombosis. Ten patients （28%） had hereditary and 10 patients （28%） acquired thrombophilic risk factors. The acquired risk factors were significantly more common in the SVT group （SVT vs BCS： 45% vs 7%, χ^2= 5.7, P = 0.02） while hereditary risk factors did not show significant differences between the two groups （SVT vs BCS： 25% vs 36%, χ^2 = 0.46, P = 0.7）. Multiple risk factors were present in one （7%） patient with BCS and in 3 patients （15%） with SVT. No risk factors were identified in 57% of patients with BCS and in 45% of patients with SVT. CONCLUSION： Hereditary and acquired risk factors play an important role in the etiopathogenesis of abdominal venous thrombosis. Acquired risk factors are significantly more common in SVT patients while hereditary factors are similar in both groups.

关 键 词：Budd Chiari syndrome Splanchnic vein thrombosis Risk factors HEREDITARY Risk comparison 

分 类 号：R575[医药卫生—消化系统] R572[医药卫生—内科学]