肝硬化患者血清糖链抗原19-9的变化  

Clinical meanings of serum CA19-9 level in hepatocirrhosis patients

作　　者：黄雪珍[1] 隋洪[1] 邓聚辉 

机构地区：[1]中山市小榄人民医院检验科,广东省中山528415

出　　处：《中国基层医药》2008年第7期1139-1140,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的动态观察肝硬化患者血清糖链抗原19-9（CA19-9）水平变化，建立判断预后的临界值。方法肝硬化组：乙型肝炎肝硬化患者61例，根据Child-Pugh肝功能积分法分三级，A级27例，B级20例，C级14例；健康对照组35例。采用电化学发光法测定血清CA19-9的含量，同时作肝功能常规检测。结果肝硬化组血清CA19-9水平比对照组显著升高（P〈0．005），血清CA19-9水平变化与Child-Pugh肝功能积分、总胆红素（TBiL）、丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）呈正相关，治疗后明显下降，特别是Child-Pugh A级和B级，与治疗前比较差异有统计学意义（P〈0．05），有效率分别为67％和55％。经统计学处理建立判断肝硬化预后平均血清CA19-9水平的临界值为≥（98．4±10．3）KU／L。结论肝硬化患者血清中CA19-9水平有不同程度升高，其水平≥（98．4±10．3）KU／L治疗效果及预后较差，可作为肝硬化患者肝功能损害程度及预后判断的指标。Objective To explore the clinical meanings of serum CA19-9 level in hepatocirrhosis patients. Methods 61 hepatitis B and hepatocirrhosis patients were as treatment group, and 35 normal were as control group. The content of serum CA19-9 was measured by electrochemistry lighting and the liver function was determined too. According to Child-Pugh liver function integral method, the treatment group was divided into 27 cases of A grade,20 cases of B grade and 14 cases of C grade. Results The serum CA19-9 level in hepatocirrhosis patients was higher than that of normal group significantly（P 〈 0. 005）. The serum CA19-9 level decreaed obviously through the treatment ,thereinto A and B grade fell evidently in the Child-Pugh liver functi6n integral method（ P 〈 0. 005）. C grade was not significantly different（P〈 0.05）. The serum CA19-9 level was positively associated with TBiL,ALT and AST of liver function integral method. Conclusion The serum CA19-9 level of hepatocirrhosis patients is improved in different degrees. And it can be a prognostic target and used to estimate the degree of damage of liver function of hepatocirrhosis patients.

关 键 词：肝硬化 CA-19-9抗原 化学发光 

分 类 号：R575[医药卫生—消化系统]