生胃酮在戊四氮急性癫痫模型中的干预作用  

Intervention effects of carbenoxolone on pentylenetetrazole-induced acute seizure in rats

作　　者：徐珑珑[1] 邹明[1] 

机构地区：[1]温州医学院附属第二医院神经内科,325000

出　　处：《实用医学杂志》2008年第15期2560-2561,共2页The Journal of Practical Medicine

基　　金：温州市科委资助项目(编号:Y20060211)

摘　　要：目的:观察生胃酮在戊四氮诱发急性癫痫模型中的干预作用。方法:用戊四氮诱发急性癫痫模型,观察戊四氮及生胃酮腹腔注射各组大鼠痫性发作等级及潜伏期。结果:在急性癫痫模型中10mg/kg生胃酮组潜伏期、平均痫性发作等级与致痫组相比差异无显著性,20mg/kg生胃酮组平均潜伏期较致痫组明显延长(P<0.01),平均痫性发作等级与致痫组及10mg/kg生胃酮组相比差异均有显著性(P<0.01)。结论:生胃酮有较明确的抗癫痫作用,在一定范围内有剂量依赖性。Objective To investigate the intervention effects of carbenoxolone on pentylenetetrazole-induced acute seizure in rats. Methods The murine model of acute seizure was established by induction of pentylenetetrazole. The scale and latency of each seizure onset were observed after intraperitoneal injections of pentylenetetrazole and carbenoxolone. Results There were no significant differences between the epileptic rats and those receiving 10 mg/kg of carbenoxolone in the average latency and scale of seizure onset, The average latency was markedly longer in the rats receiving 20 mg/kg of carbenoxolone than in the epileptic rats （P 〈 0.01 ） and the average scale of seizure onset differed significantly between the rats receiving 20 mg/kg of carbenoxolone and the epileptic rats or those receiving 10mg/kg of carbenoxolone （P 〈 0.01 ）. Conclusion Carbenoxolone plays a protective role in the onset of seizure in a dose-dependent manner.

关 键 词：癫痫 戊四唑 生胃酮 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R595.3[医药卫生—临床医学]