p16、FGFR-4及c—erbB-2的表达对垂体腺瘤生物学行为的意义  

Significance of protein expressions of p16, FGFR-4 and c-erbB-2 for the determination of biological behaviors of pituitary adenomas

作　　者：周崧[1] 殷晓璐[2] 许雁萍[2] 江基尧[1] 

机构地区：[1]上海交通大学医学院附属仁济医院神经外科,上海200127 [2]上海交通大学医学院附属仁济医院病理科,上海200127

出　　处：《中华神经医学杂志》2008年第8期784-787,792,共5页Chinese Journal of Neuromedicine

摘　　要：目的探讨p16、FGFR-4及c-erbB-2表达与垂体腺瘤生物学行为的关系。方法应用免疫组化染色检测95例垂体腺瘤p16、FGFR-4及c-erbB-2的表达水平，并对其中30例患者进行了5年随访观察。结果垂体腺瘤p16、FGFR-4及c-erbB-2的阳性表达率分别为54．7％、98．9％和82．4％。p16表达在内分泌功能组（有功能组33例；无功能组19例）、肿瘤大小组（0级4例；Ⅰ级13例：Ⅱ级32例；Ⅲ级3例）、侵袭性组（有侵袭性3例；无侵袭性23例）以及随访组（复发1例：无复发15例）中比较差异有统计学意义（P〈0．05）。FGFR-4的阳性表达与在肿瘤大小组间差异有统计学意义（P〈0．05）（0级：阳性5例、强阳性2例；Ⅰ级：阳性4例、强阳性10例；Ⅱ级：阳性12例、强阳性48例；Ⅲ级：阳性4例、强阳性9例），在侵袭组间差异无统计学意义。FGFR-4与c-erbB-2的表达呈正相关．而p16与c-erbB-2的表达呈负相关。结论p16的表达缺失对垂体腺瘤的增殖、侵袭以及复发具有十分重要的意义；FGFR-4的过度表达对垂体腺瘤的增殖起着重要作用；FGFR-4、c-erbB-2及p16在肿瘤形成过程中可能通过相互的协同作用调控肿瘤细胞的生长周期。Objective To study the relationship between protein expressions of p16, FGFR-4 and c-erbB-2 and biological behaviors of pituitary adenomas. Methods Imrnunohistochemical techniques were used to detect the expression levels of p16, FGFR-4 and c-erbB-2 in the 95 cases with pituitary adenomas and 30 cases among them were followed up for 5 years. Results The positive expression rates of p16, FGFR-4 and c-erbB-2 were respectively 54.7%, 98.9% and 82.4%. Significant differences in the p16 expression existed among the endocrine function groups （with function, 33 cases; without function, 19 cases）, Hardy＇s classification groups （grade 0. 4 cases; grade 1, 13 cases; grade 2, 32 cases; grade 3, 3 cases）, invasiveness groups （invasive, 3 cases; noninvasive, 23 cases） and follow-up groups （recurred, 1 case; not recurred, 15 cases）. The positive expression of FGFR-4 was obviously correlated with the size of pituitary adenomas （grade 0： ＂＋-＋＋＂, 5 cases and ＂＋＋＋＂, 2 cases; grade 1： ＂＋-＋＋＂, 4 cases and ＂＋＋＋＂, 10 cases; grade 2： ＂＋-＋＋＂, 12 cases and ＂＋＋＋＂, 48 cases; grade 3： ＂＋-＋＋＂, 4 cases and ＂＋＋＋＂, 9 cases）. The expression of FGFR-4 was not related to invasiveness. The expressions of FGFR-4 and p16 were respectively positively and negatively correlated with that of c-erbB-2. Conclusions The decreased expression of p16 was responsible for the proliferation, invasiveness and recurrence of pituitary adenomas, while the increased expression of FGFR-4 plays an important role in the proliferation of pituitary adenomas. FGFR-4, c-erbB-2 and p16 may regulate cell growth cycle of tumor cells through synergic effects in the process of oncogenesis.

关 键 词：垂体腺瘤 P16 成纤维生长因子受体-4 C—erbB-2 细胞生理学 

分 类 号：R736.4[医药卫生—肿瘤]