模拟青少年脊柱多层CT低剂量扫描的动物实验  

Animal Experiment of Low-dose Scanning of Multi-slices CT on Simulated Adolescent Vertebral Column

作　　者：彭谦[1] 范淼[1] 严超贵[1] 张晋昕[2] 孟悛非[1] 陈星[1] 

机构地区：[1]中山大学附属第一医院放射科,广东广州510080 [2]中山大学公共卫生学院统计学教研室,广东广州510080

出　　处：《中山大学学报（医学科学版）》2008年第4期431-434,共4页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：2007广东省科技计划项目(2007B060401012)

摘　　要：【目的】通过动物模型逐步降低管电流,初步摸索出相对应的模拟显示青少年脊柱正常解剖结构的低剂量多层CT扫描的最低管电流。【方法】以30～40kg幼猪模拟青少年进行脊柱多层CT扫描。先行预试验,初步确定最低剂量值后,进行实验。每只幼猪扫描常规剂量≥200mA(A组)、最低剂量值(C组)、其上位10mA(B组)、下位10mA(D组)进行平扫。将扫描后重建图像随机交由两位有经验的高年资放射学医师采用双盲法进行阅片、评价图像质量,以取得一致意见为准。以常规剂量图像为基础片,从图像伪影、质地(噪声)、脊柱结构(骨皮质、骨松质、骨小梁)的显示、脊柱与周围组织的对比四个方面评价,进行配对设计两样本的卡方检验。【结果】30mA与正常剂量组CT扫描图像经统计学分析,P>0.05。20mA与正常剂量组CT扫描图像经统计学分析,P<0.05。30mA可以获得与正常剂量组同样显示清晰的CT图像。本动物实验得到模拟青少年脊柱多层CT低剂量扫描管电流的最低值是30mA。【结论】低剂量多层CT扫描可以可获得符合临床诊断需求的脊柱结构的图像信息,因而能在青少年脊柱侧突的临床诊断中应用。[Objective] To figure out the lowest current that could manifest the normal structure of adolescent vertebral column by decreasing the current step by step in animal model. [Methods] Adolescent vertebral column were examined by multi-slices CT and modeled by pigs weighted 30 - 40 kg. Preliminary test were done at first and the lower current dose was found. The pigs were scanned respectively by the routine dose （Group A）, the lower dose （Group C）, the dose above （Group B） and below （Group D） 10mA to the lower dose. The reconstruct image quality was evaluated by two radiologists randomly with double-blind method. The image quality of plain film which was scanned by routine dose was used as the standard. The image qualities of all the films were evaluated respectively from artifact, noise, display of vertebral column structure （cortical bone, cancellous bone, trabecular bone）, contrast of vertebral column and adjacent structure. All the results were analyzed by Chi-square test. [Results] There was no significantly statistical difference between Group A and Group B, or between Group A and Group C（ P 〉 0. 05）. There was significantly statistical difference between Group A and Group D （ P 〈 0.05）. The CT images obtained by Group C were the same clear as those images obtained by Group A. The lowest dose for simulated vertebral column of multi-slices CT was 30 mA. [Conclusion] Images that satisfied clinical demand could be obtained by low dose multi-slices CT scanning, low dose multi-slices CT scanning can be used in the diagnose of adolescent scoliosis.

关 键 词：青少年 脊柱 体层摄影术 X线计算机 低剂量 

分 类 号：R814.2[医药卫生—影像医学与核医学]