颅内囊状动脉瘤的组织病理观察与分析  

Histopathological observation of intracranial berry aneurysms

作　　者：张海峰[1] 李光[2] 路喜安[1] 

机构地区：[1]山西医科大学第一临床医学院病理科,太原030001 [2]首都医科大学附属北京天坛医院病理科

出　　处：《山西医科大学学报》2008年第8期711-713,F0003,共4页Journal of Shanxi Medical University

摘　　要：目的探讨颅内囊状动脉瘤的组织病理学变化和发生规律。方法采用特殊染色(包括弹力纤维和肌纤维等)和免疫组化标记方法对18例颅内囊状动脉瘤组织细胞变化进行镜下观察和分析。结果100%(18/18)囊状动脉瘤均发生弹力板断裂;中膜(如平滑肌成分)缺如可见于25%(2/8)大动脉动脉瘤和70%(7/10)中小动脉瘤。结论囊状动脉瘤组织学的最基本改变为弹力板断裂,中膜缺如多见于中小动脉瘤。Objective To investigate histopathological changes of intracranial berry aneurysm and its developing mechanism. Methods Histopathological changes in 18 cases of intracranial berry aneurysrns were observed using special stain and immunohisto- chemical methods. Results All the cases showed splitting of elastic laminae. Defects of medien layers were found in large cerebral artery aneurysms in 2 cases（25 % ）and in middle and small cerebral artery aneurysms in 7 cases（70 % ）. Conclusion The most ba- sic histopathological feature of berry aneurysrns is the splitting of elastic laminae. Defects of medien layers are mainly found in middle and small cerebral artery aneurysms.

关 键 词：颅内囊状动脉瘤 特殊染色 免疫组织化学 

分 类 号：R739.41[医药卫生—肿瘤]