男性不育患者Y染色体微缺失检测意义的探讨  

Significance of Y Chromosome Microdeletion Detection in Infertile Men

作　　者：邹红艳[1] 孙波澜[1] 邹湘丽[1] 吴方贵[1] 

机构地区：[1]深圳市罗湖区人民医院生殖中心,518000

出　　处：《中国计划生育学杂志》2008年第7期421-423,共3页Chinese Journal of Family Planning

摘　　要：目的:研究男性不育,尤其特发无精和严重少精者与Y染色体微缺失的关系及缺失类型。方法:运用PCR技术对294例男性不育患者进行Y染色体微缺失检测。结果:21例存在Y染色体微缺失,其中16例为AZF(c+d)联合位点缺失(临床表现13例为严重少弱精、3例为无精症),1例为AZF(b+c+d)联合位点缺失(临床表现为无精症),1例为AZFb位点SY143,SY127,SY124,SY134,SY128,SY133联合缺失(临床表现为无精症)。1例为AZFbSY133缺失,2例为AZFbSY127缺失(临床表现均为少弱精症)。结论:Y染色体微缺失多表现为多个位点的联合缺失,可造成生精障碍或阻滞,表现为严重少精或无精症。Objective： To study the relationship between infertile men with idiopathic azoospermia and oligospermia and the Y chromosome mierodeletion and the types of mierodeletion. Methods： Y chromosome mierodeletion detection of 294 eases with male infertility were screened by PCR. Results： 21 infertile men were identified as Y chromosome mierodeletion： Azoospermia factor（AZF） （e ＋ d） deletion （16 eases） , AZF（ b ＋e＋d） deletion（1 ease）, SY143, SY127, SY124, SY134, SY128, SY133 deletion in AZFb region（1 ease）, AZFb SY133 deletion（ 1 ease）, AZFb SY127 deletion（2 eases）. Conclusion： Y chromosome deletions can occur in many regions, which can lead to idiopathic azoospermia and oligospermia in men.

关 键 词：Y染色体 男性不育 微缺失 

分 类 号：R698.2[医药卫生—泌尿科学] R256.56[医药卫生—外科学]