子宫内膜癌中MTS1/p16基因缺失的研究  

Deletion of MTS1/p16 gene in endometrial carcinoma

作　　者：周春晓[1] 孙建衡[1] 陆士新[1] 刘海玲[1] 苏涛 金顺钱[1] 盛修贵[1] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院肿瘤研究所

出　　处：《中华肿瘤杂志》1997年第6期404-406,共3页Chinese Journal of Oncology

摘　　要：目的探讨ＭＴＳ１／ｐ１６基因缺失与子宫内膜癌发生发展的关系。方法采用聚合酶链式反应（ＰＣＲ）技术，扩增３２例子宫内膜癌组织的ＭＴＳ１／ｐ１６基因。结果３２例子宫内膜癌组织中，有６例出现ＭＴＳ１／ｐ１６基因缺失，缺失率为１８．８％；癌旁组织、正常子宫内膜组织和组织分级Ｇ１的癌组织未见ＭＴＳ１／ｐ１６基因缺失。结论ＭＴＳ１／ｐ１６基因缺失可能与子宫内膜癌病程进展有关，应对其进一步研究。Objective To investigate the possible relationship between deletion of MTS1/p16 gene and progression of endometrial carcinoma.Methods Thirty two primary endometrial carcinoma, 7 tumor adjacent endometrial tissue and 10 normal endometrial tissue specimens were examined for homozygous deletion of MTS1/p16 gene by polymerase chain reaction based analysis.Results Of 32 endome trial cancer specimens, 6(18.8%) showed homozygous deletion of MTS1/p16 gene. No deletion was detected in the tumor adjacent and normal endometrial tussues. Nor was it detected in well differentiated endometrial carcinoma.Conclusions Deletion of MTS1/p16 gene might contribute to the progression of endometrial carcinoma and could be served as indicator for predicting prognosis.

关 键 词：子宫肿瘤 MTS1/p16基因 基因缺失 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]