儿童青少年淋巴系统恶性肿瘤患者血清血管内皮生长因子水平与临床关系  

Relationship between serum VEGF level and clinical feature in children and adolescent with lymphoid malignancy

作　　者：罗文标[1] 孙晓非[1] 张昌卿[2] 夏奕[1] 甄子俊[1] 王智辉[1] 凌家瑜[1] 郑磊[1] 林慧[1] 

机构地区：[1]中山大学肿瘤防治中心内科,华南肿瘤学国家重点实验室,广州510060 [2]中山大学肿瘤防治中心内科,华南肿瘤学研究所,广州510060

出　　处：《白血病．淋巴瘤》2008年第4期261-263,共3页Journal of Leukemia & Lymphoma

摘　　要：目的探讨儿童青少年非霍奇金淋巴瘤（NHL）和急性淋巴细胞性白血病（ALL）患者血清血管内皮生长因子（sVEGF）水平与临床的关系。方法使用ELISA法检测101例3个月。20岁NHL和ALL患者初诊时sVEGF水平，并对其中获得完全缓解（CR）的61例患者进行治疗前后sVEGF水平的比较。结果81例初诊NHL患者sVEGF浓度为567．70ng／L，明显高于正常对照值（P〈0．001），其中49例CR患者sVEGF浓度为253．90ng／L，与治疗前比较差异有统计学意义（P〈0．001），与正常值相比差异无统计学意义。初诊NHL患者sVEGF与临床分期、B症状、性别、PS评分、巨大肿块和血清LDH等临床指标无明显相关。20例ALL患者初诊时sVEGF浓度198．60ng／L，与正常值相比差异无统计学意义。其中12例CR患者sVEGF浓度为181．73ng／L，与治疗前水平及正常值相比，差异均无统计学意义。结论初诊儿童青少年NHL患者sVEGF水平升高，CR后下降，NHL患者sVEGF水平与临床指标无相关性。初诊ALL患者的sVEGF水平无明显升高，治疗前后无明显变化。Objective To investigate the relationship between serum-VEGF （sVEGF） and clinical features in children and adolescent patients with non-Hodgkin lymphoma （NHL） and acute lymphoblastic leukemia（ALL）. Methods The sVEGF in 101 of pretreated NHL and ALL patients were detected by enzyme-linked immunosorbent assay （ELISA）. The sVEGF prior and post-treatment were compared in 61 patients who achieved complete remission （CR）. Results The median sVEGF was 567.70 ng/L in 81 prior-treated NHL patients, It was significantly higher than that in normal eontrols（P 〈0.001）. The median sVEGF was 253.90 ng/L in 49 patients with CR, which was significantly different compared to pretherapeutic level （P 〈0.001）, whereas no statistical difference was observed compared to the normal controls. No relationships were found between sVEGF and clinical indexes such as clinical stage, ＂B＂ symptoms, gender, performance status （PS） score, bulk and serum lactate dehydrogenase （LDH） et al in untreated NHL patients. The median sVEGF was 198.60 ng/L in 20 untreated ALL patients, which was no statistically different in comparison with that of normal controls. And the median sVEGF was 181.73 ng/L in 12 of the CR ALL patients, which was not statistically different in comparison with that in prlor-treatment group or normal controls. Conclusion This study showed that the sVEGF in untreated children and adolescent patients with NHL were higher than that of normal controls. The high sVEGF dropped after achieving CR. There was no relationship between the level of sVEGF and clinical characteristics in the NHL patients. The sVEGF level in untreated ALL patients was not different compared to that of the normal controls, and there was no change for sVEGF after chemotherapy in ALL patients.

关 键 词：血清内皮生长因子 淋巴瘤 非霍奇金 白血病 淋巴细胞 急性 儿童 青少年 

分 类 号：R733.1[医药卫生—肿瘤]