异基因外周血干细胞移植后外周血出现幼稚粒细胞与白血病复发的关系  

The relationship between immature granulocyte in peripheral blood and leukemia relapse after allogeneic peripheral blood stem cell transplantation

作　　者：李玲[1] 钟笛[1] 袁海龙[1] 哈力达·亚森[1] 江明[1] 曲建华[1] 张琼[1] 温丙昭[1] 

机构地区：[1]新疆医科大学第一附属医院血液科新疆血液病研究所,乌鲁木齐830011

出　　处：《白血病．淋巴瘤》2008年第4期271-273,共3页Journal of Leukemia & Lymphoma

基　　金：新疆维吾尔自治区高新技术项目（200511109）

摘　　要：目的了解异基因外周血干细胞移植（allo-PBSCT）后白血病复发与外周血幼稚粒细胞的关系。方法97例白血病患者经allo-PBSCT治疗，于14、30、60、90、120、180d及1年以后骨髓随访时同时观察外周血幼稚粒细胞出现情况，分析与白血病复发的关系。结果97例中，15例发生白血病复发。在30d及其以后外周出现幼稚粒细胞的57例中，复发14例，复发率24．6％，而30d及其以后外周血未出现幼稚粒细胞者的40例中仅有1例复发，复发率2．5％（P〈0．05）。复发与不复发者移植物抗宿主病（GVHD）差异无统计学薏：义（P〉0．05）。结论白血病复发与移植后外周血幼稚粒细胞有关．复发后治疗难度大，预后差。Objective To analyze the relationship between immature granuloeytes in peripheral blood and leukemic relapse after allogeneic peripheral blood stem cell transplantation. Methods The bone marrow was followed up and immature granulocytes in peripheral blood smear were evaluated on 14 days, 30 days, 90 days, 180 days, 1 year after allo-PBSCT for 97 cases with leukemia. The relationship between frequency of immature granulocytes and leukemic relapse was analysed. Results 15 of 97 patients relapsed on and after 30 days. The relapse rate was 24.6 % in 14 of 57 patients with immature granulocytes occurred peripheral blood, and the relapse rate was 2,5 % in patients without immature granuloeytes of peripheral blood （P 〈0.05）. The incidences of GVHD in relapse group and no relapse group were not statistically different （P 〉 0.05）. Conclusion There was a relationship between persistent immature granuloeytes of peripheral blood and leukemic relapse, and the treatment became difficult after relapse and the prognosis was poor.

关 键 词：白血病 外周血干细胞移植 复发 粒细胞 

分 类 号：R733.71[医药卫生—肿瘤]