重组人白细胞介素-11治疗急性白血病化疗后血小板减少疗效分析  

Investigation of the treatment of recombinant human interleukin-11 to chemotherapy-induced thrombocytopenia in acute leukemia

作　　者：李发菊[1] 周玉萍[1] 王建英[1] 韩丽英[1] 吴鹏强[1] 

机构地区：[1]泸州医学院附属医院血液科,646000

出　　处：《白血病．淋巴瘤》2008年第4期274-275,共2页Journal of Leukemia & Lymphoma

摘　　要：目的观察重组人白细胞介素-11（rhIL-11）对急性白血病（AL）化疗后血小板（Plt）减少的疗效。方法对42例AL（治疗组）化疗后Plt〈20×10^9／L的患者皮下注射rhIL-111．5mg／d，用至Plt≥40×10^9／L停药；对其中17例初诊急性髓系白血病（AML）完成2个疗程化疗后统计疗效，并以35例未加用rhIL-11的AL患者和其中15例初诊AML（对照组）完成2个疗程化疗患者作对照。结果治疗组Plt升到≥40×10^9／L所需时间平均为（9．8±2．7）d，短于对照组（14．6±4．8）d（P〈0．05）；治疗组在第2个疗程化疗后Plt〈15×10^9／L的患者有3例（17．6％），明显少于对照组10例（66．7％）（P〈0．05）；第2个疗程化疗前Plt水平和化疗后Plt最低平均水平，治疗组为（173．7±81．2）×10^9／L和（23．5±18．3）×10^9／L高于对照组（99．6±74．5）×10^9／L和（10．2±9．8）×10^9／L（P〈0．05）；治疗组和对照组的完全缓解（CR）率分别是70．6％和73．3％，有效（CR＋PR）率分别是82．4％和86．7％，二组比较差异无统计学意义（P〉0．05）。结论rhIL-11可安全有效地促进AL化疗后Plt恢复，而且疗效持久。Objective To investigate the treatment of recombinant human interleukin-11 （rhIL-11） to chemotherapy-induced thrombocytopcnia in acute leukemia （AL）. Methods 42 AL patients whose platclct count dropped below 20×10^9/L after chemotherapy received rhIL-11 by 1.5 mg daily until the platclct count was increased above 40×10^9/L. The efficiency of chemotherapy to 17 newly diagnosed acute myclocytic leukemia （AML） patients was evaluated after receiving two periods of chemotherapy. 35 AL patients and 15 newly diagnosed AML patients were used as controls. Results The mean time of platclct count increasing from 20×10^9/L to above 40×10^9/L was shorter in treating group [（9.8±2.7）d] than in control group [（14.6±4.8）d]. The number of patients whose platclet 〈15×10^9/L was less in treating group than in control group after second chemotherapy, and the minimum mean count of platclet was higher in treating group[（23.5±18.3）×10^9/L] than that in control group [（10.2±9.8）×10^9/L]. CR and CR＋PR rate were not different between treating group and control group. Conclusion rhIL-11 can safely and effectively promote chemotherapy-induced platelet recovery in patients of acute leukemia with persistent affection.

关 键 词：白血病 药物疗法 白细胞介素-11 血小板减少 

分 类 号：R733.71[医药卫生—肿瘤]