EMMPRIN/CD147和MMP-2在喉癌组织中的表达及其与预后的关系  

Expression of EMMPRIN/CD147 and MMP-2 in Laryngeal Carcinoma and the Correlation to Prognosis

作　　者：苟小霞[1] 金风[1] 何常[1] 吴伟莉[1] 董洪敏[1] 陈露[1] 曾英[1] 

机构地区：[1]贵州省肿瘤医院头颈肿瘤科贵阳医学院,贵州550003

出　　处：《肿瘤预防与治疗》2008年第3期263-266,269,341,共6页Journal of Cancer Control And Treatment

摘　　要：目的:探讨细胞外基质金属蛋白酶诱导因子(extracellular matrix metalloproteinase inducer,EMMPRIN/CD147)和基质金属蛋白酶-2(matrix metalloproteinases-2,MMP-2)在喉癌的表达,两者的表达关系及其与喉癌浸润、转移和预后的关系。方法:采用免疫组织化学两步法检测48例喉癌组织、10例喉乳头状瘤和15例喉炎中CD147、MMP-2的表达,并与临床病理特征和预后进行对比。结果:喉癌标本中CD147和MMP-2的阳性表达率分别为87.5%(42/48)和75.0%(36/48),明显高于喉炎组26.7%(4/15)和6.7%(1/15),CD147和MMP-2的阳性表达与喉癌临床分期和淋巴结转移情况有关,CD147和MMP-2在喉癌的表达一致率为68.8%,两者表达之间存在正相关(r=0.736,P(0.001),单因素生存分析显示CD147和MMP-2表达强阳性的喉癌患者生存率低于表达阴性组。结论:CD147和MMP-2与喉癌侵袭与转移有关,CD147与MMP-2的产生有密切的关系,两者可作为喉癌判断临床预后的参考指标。Objective： To investigate the expression of extracellular matrix metaUoproteinase inducer （EMMPRIN/CD147）and matrix metaUoproteinases-2 （MMP-2） in human laryngeal carcinoma, and to study their relationship with the invasion, metastasis and prognosis. Methods： The expression of CD147 and MMP-2 was detected using immunohistochemical staining in 48 specimens from laryngeal carcinoma, 10 specimens from laryngeal papilloma and 15 specimens from laryngitis, and the results were compared to clinical pathological features and prognosis. Results： The positive rates of CD147 and MMP-2 were significantly higher in laryngeal carcinoma than in laryngitis tissue （87.5% ,75.0% vs 26.7% ,6.7% ） o The intensive expression of CD147 and MMP-2 were correlated with the clinical stage and the situation of lymph nodes matastasis. The coexpression rate of CD147 and MMP-2 in laryngeal carcinoma was 68.8%. Positive correlation was found between the CD147 and MMP-2（ r =0. 736,P 〈 0.001 ）. Univariable survival analysis indicated that overall survival rate was lower in patients w/th intensive positive expression of CD147 and MMP-2 than in patients with negative expression. Conclusion： CD147 and MMP-2 may play a role in invasion and metastasis of laryngeal carcinoma. Increased MMP-2 might be induced by CD147 expressed in laryngeal tumor cells. They may be prognostic factors of laryngeal carcinoma.

关 键 词：喉癌 细胞外基质金属蛋白酶诱导因子(EMMPRIN/CD147) 基质金属蛋白酶-2(MMP-2) 免疫组织化学 

分 类 号：R739.65[医药卫生—肿瘤] R730.2[医药卫生—临床医学]