MMP-9在宫颈上皮内瘤变及宫颈癌中的表达  

Expression of MMP-9 in Cervical Intraepithelial Neoplasia and Cervical Carcinoma

作　　者：黄海萍[1] 叶学正[1] 周琦[1] 张代奎[1] 唐郢[1] 

机构地区：[1]重庆市肿瘤研究所,重庆400030

出　　处：《肿瘤预防与治疗》2008年第3期267-269,共3页Journal of Cancer Control And Treatment

摘　　要：目的:观察基质金属蛋白酶MMP-9在宫颈上皮内瘤变(CIN)及宫颈鳞癌中的表达,探讨MMP-9在CIN的发展及宫颈鳞癌侵袭、转移中的意义。方法:对79例CIN、79例宫颈鳞癌及16例正常宫颈组织采用免疫组化SP法进行检测。结果:MMP-9在正常宫颈鳞状上皮、CIN及宫颈鳞癌肿瘤细胞胞浆中的表达有统计学差异(P<0.01);MMP-9在CIN、宫颈鳞癌各病理分级中的表达无统计学差异(P>0.05),但其阳性表达率随各病理等级的增高而上调;MMP-9在各临床分期中的表达无统计学差异(P>0.05);但MMP-9的阳性表达与宫颈鳞癌有无淋巴结转移有统计学差异(P<0.05)。结论:MMP-9与CIN的发展有关,是宫颈鳞癌发生过程中的早期事件。MMP-9与宫颈癌的侵袭、转移有密切关系。Objective： To observe the expression of matrix metalloproteinase MMP-9 in cervical intraepithelial neoplasia （CIN） and cervical carcinoma, and to investigate it＇ s significance in the development of CIN and the invasion of cervical squamous cell carcinoma. Methods： Immunohistochemistry was used to detect the expression of MMP-9 in 79 cases of CIN, 79 cases of cervi- cal squamous ceil carcinoma and 16 cases of normal cervical specimens. Results： The expression of MMP-9 in the cytoplasm of the normal cervical specimens , CIN and the cervical squamous ceil carcinoma showed significant difference （P 〈 0. 01 ） ;there was no sta- tistic relationship between the expression of MMP-9 in CIN, cervical squamous cell carcinoma＇ s pathologic ratings （ P 〉 0. 05 ）, but the positive rate of MMP-9 is higher in the higher differentiation carcinoma ;the expression of MMP-9 in several clinical stages showed no significant difference （ P 〉 0.05 ） ; but the MMP-9 expression had statistic relationship with lymph nodes metastasis （ P 〈 0. 05 ）. Conclusion： MMP-9 is associated with the development of CIN, the lower pathological stage of cervical squamous ceil carcinoma. MMP-9 is correlated with the invasion and metastasis of cervical squamous ceil carcinoma.

关 键 词：宫颈上皮内瘤变 宫颈鳞癌 MMP-9 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤] R730.2[医药卫生—临床医学]