乳腺癌患者术后预后相关因素分析  

Analyses of prognostic factors for breast cancer patients

作　　者：李志华 曹亚丽 龚宇 苏逢锡[2] 姚和瑞[3] 

机构地区：[1]南昌市第三医院乳腺肿瘤中心,江西南昌330009 [2]中山大学附属第二医院乳腺肿瘤中心,广州510120 [3]中山大学附属第二医院肿瘤科,广州510120

出　　处：《岭南现代临床外科》2008年第4期247-249,共3页Lingnan Modern Clinics in Surgery

基　　金：广东省医学科研基金资助课题(A2005226);广东省自然科学基金资助课题(7001592);广东省科技计划资助课题(2006B36002010)

摘　　要：目的探讨影响乳腺癌患者术后预后的相关因素。方法对101例乳腺癌患者,进行回顾性研究。本组病例采用Log-rank单因素分析和COX多因素模型的分析方法分析乳腺癌预后的相关指标。结果Log-rank单因素分析结果提示肿瘤大小(直径>5cm)、病理分级、淋巴结转移、HER-2/neu和CD44五个因素是乳腺癌的预后因素(P均<0.05),ER和PR不能作为乳腺癌的预后指标;进一步采用COX多因素分析结果提示,仅有HER-2/neu、肿瘤大小、淋巴结转移和病理分级是乳腺癌预后的独立预测指标。结论肿瘤大小、病理分级、淋巴结转移、HER-2/neu是临床判断乳腺癌预后有价值的指标。Objective To investigate breast cancer. Methods 101 cases with breast the influencing prognostic factors for the patients with cancer were analyzed retrospectively. The influencing prognostic factors for these patients were analyzed by Log-rank single factor analysis and Cox Multiple factors analysis. Results Log-rank single factor analysis results suggested that tumor size （diameter 〉 5 cm）, pathological grading, lymph node metastasis, HER-2/neu and CD44 were five factors of breast cancer prognostic factors, ER and PR can not be used as breast cancer prognosis indexes; Cox Multiple factors analysis showed that HER-2/neu, tumor size,pathological grade, lymph node metastasis were independent predicted factors of breast cancer,but CD44 was not an independent prognostic index. Conclusion Tumor size, pathological grading, lymph node metastasis, HER-2/neu are the valuable clinical prognostic indicators of breast cancer.

关 键 词：乳腺癌 预后 COX多因素分析 

分 类 号：R737.9[医药卫生—肿瘤]