强记汤对记忆获得、巩固和再现障碍小鼠模型的影响  

Effect of Optimized Memory-Enhancing Soup on Memory Improving

作　　者：李凡[1] 吴正治[1] 李映红[1] 陈曼茵[1] 杨敏[1] 

机构地区：[1]南方医科大学附属深圳医院,广东深圳518035

出　　处：《中医药导报》2008年第8期9-11,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:研究中药古方强记汤对记忆获得、巩固和再现障碍模型的影响。方法:将强记汤以29.3 g/kg量经口灌胃给予昆明种小鼠,连续5 d,第6 d给药1 h后分别制备记忆获得、巩固和再现障碍模型,第7 d给药0.5-1 h后分别用跳台法和避暗法测试记忆成绩。结果:强记汤水煎液对动物记忆障碍模型小鼠记忆成绩中的潜伏时间、错误次数与模型对照组比较,差异均有统计学意义(P<0.01)。结论:中药古方强记汤对实验动物被动回避反应能力的记忆获得、记忆保持及记忆再现均有改善作用。Objective： To explore the effects of traditional Chinese medicine ancient complex prescription Memory-Enhancing Soup （MES） on memory improvement of dysmnesia animal, and verify the promotion of optimized MES on the expression of learning and memory molecular switch CREB gene. Methods： The SPF mice were treated with MES in dose of 29.3 g/kg and 18.6 g/kg per day respectively by intragastric administration for five days continuously. And then, the various dysmnesia mouse models were prepared respectively with Scopolamine（3 mg/kg）, Cycloheximide（120 mg/kg） by intraperitoneal injection and 40% alcohol（0.1 ml/10 g body weight） by intragastric administration on the sixth day. Next day, memory result was estimated by using Step-down Test and Dark-avoiding Test after the mice were administered for half or an hour. Results： MES improved the memory functions about latent time and error frequency of dysmnesia mouse models obviously comparing with model control group（P 〈0.01）.Conclusion： Traditional Chinese medicine ancient complex prescription MES could improve the memory acquirement, retention and reappearance of passive avoidance response ability.

关 键 词：强记方 记忆障碍 记忆成绩 

分 类 号：R285.5[医药卫生—中药学]