^1H-MRS和SPECT对脑肿瘤放疗后复发与放射性坏死的鉴别诊断价值  

Differential diagnosis value of 1H-MRS and SPECT on necrosis and brain neoplasm relapse after radiotherapy

作　　者：张泉[1] 柏根基[1] 

机构地区：[1]南京医科大学附属淮安一院,江苏淮安223300

出　　处：《山东医药》2008年第25期22-24,共3页Shandong Medical Journal

基　　金：南京医科大学科技发展基金项目(07NMUM089);淮安市科技局科技发展项目(HAS07032)

摘　　要：目的探讨质子磁共振波谱（^1H-MRS）和^99mTc-甲氧基异丁基异腈（MIBI）单光子发射计算机断层显像（SPECT）对脑肿瘤患者放疗后复发（下称复发）与放射性坏死（下称坏死）的鉴别诊断作用。方法对35例脑肿瘤患者进行^1H-MRS和SPECT检查。结果复发20例，^1H-MRS表现为胆碱（Cho）波上升，N-乙酰天门冬氨酸（NAA）波下降，乳酸和脂质波升高；^99mTc-MIBI摄取指数T／C比值1．9～6．7（3．7±1．5）。坏死15例，^1H-MRS表现为Cho、NAA、肌酸波降低；^99mTc-MIBI摄取指数T／C比值0．8～1．8（1．1±0．3）。两组比较均有统计学差异（P均〈0．01）。结论’H．MRS和SPECT检查对脑肿瘤复发及坏死有鉴别诊断价值。Objective To investigate the differential diagnosis value of ^1H magnetic resonance spectroscopy（^1H- MRS） and ^99mTc-methoxy isobutyl isonitrile（MIBI） single photon emission computed tomography（SPECT） on postradiotherapy relapse and radionecrosis. Methods ^1H-MRS and SPECT were performed in all 35 cases. Results There were 20 cases of recurrence of brain neoplasm. It showed that the rise of choline（Cho） wave, lactic acid and lipid wave, the fall of Naminosuccinic acid（NAA） wave on ^1H-MRS. ^99mTc-MIBI uptake index T/C was 1.9-6.7 （3.7 ±1.5）. There were 15 brain neoplasm patients with cellular necrosis, it showed that Cho, NAA, creatine wave depressed. ^99mTc-MIBI uptake index T/C 0.8 -1.8 （1.1±0.3）. There were statistically different in the above indexes by the two detection methods （P all 〈0.01）. Conclusions ^1H-MRS and SPECT are helpful methods to determine recurrence or necrosis of brain neoplasm after radiotherapy.

关 键 词：脑肿瘤 复发 坏死 放射性 质子磁共振波谱 单光子发射计算机断层显像 

分 类 号：R739.4[医药卫生—肿瘤]