氧化加碱处理Ti-24Nb-4Zr-7.9Sn合金表面的生物相容性研究  

Biocompatibility of bioactivated Ti-24Nb-4Zr-7.9Sn alloy surface for implantation

作　　者：赵永康[1] 王秋旭[1] 刘维贤[1] 郑彩云[2] 李述军[2] 

机构地区：[1]中国医科大学附属第二医院口腔科,辽宁沈阳110004 [2]中国科学院金属研究所钛合金研究部,辽宁沈阳110016

出　　处：《东南大学学报（医学版）》2007年第4期252-256,共5页Journal of Southeast University(Medical Science Edition)

基　　金：辽宁省教育厅科学研究计划资助项目(202013122)

摘　　要：目的:检测氧化加碱处理的Ti-24Nb-4Zr-7.9Sn合金表面的生物相容性。方法:对具有自主知识产权的Ti-24Nb-4Zr-7.9Sn(TNZS)亚稳β型超低模量钛合金和纯钛(以下简称CpTi),采用独立开发的氧化加碱处理方法进行表面处理,通过体外模拟实验和体内植入实验对材料生物相容性进行检测。结果:X射线衍射分析结果表明,在模拟人体体液(SBF)和快速生物活性鉴别液(FCS)中浸泡的氧化加碱处理TNZS表面形成骨样羟基磷灰石层,在SBF中浸泡后的氧化加碱处理TNZS表面生成的物质很薄。TNZS和CpTi二种材料表面处理组的直接骨结合率两者没有显著性差异(P>0.05),未表面处理组直接骨结合率两者也没有显著性差异(P>0.05);TNZS和CpTi二种材料的表面处理组和未表面处理组均有显著性差异(P<0.05)。结论:氧化加碱性活化方法是一种良好的钛合金表面处理方法。Objective To investigate the biocompatibility of Ti-24Nb-4Zr-7.9Sn alloy that were oxidated and alkali treated. Methods Low modulus β type titanium alloys Ti-24Nb-4Zr-7.9Sn （ the alloy is abbreviated as TNZS belew） were oxidated and alkali treated. The biocompatibility were investigated by both in vitro and in vivo test. Results The X- ray diffraction analysis （XRD） showed that bone-like apatite layer formed TNZS soaked in fast calcification solution （FCS） and simulated calcification solution（SBF） ,but the apatite layer on SBF-soaked TNZS was thinner. There was no significant difference of direct contact length fraction, indicating the surface treatment condition, between activated TNZS and activated CpTi or between unactivated TNZS and unactivated CpTi. There was a significant difference between unactivated and activated TNZS and CpTi. Conclusion Oxidation and alkali treatment is a good surface treatment method.

关 键 词：钛合金 低模量 表面处理 生物相容性 

分 类 号：R783.1[医药卫生—口腔医学]