^(99m)TC-MIBI动态显像对非小细胞肺癌化疗疗效的预测价值初探  

The Clinical Study of the Predicting Chemotherapy Response To Platin-Based Therapy in Nsclc By Early and Delay ^(99m)TC-MIBI Chest Single Photon Emission Computed Tomography

作　　者：吴立平[1] 张秀芹[1] 李凤岐[2] 甄永强[1] 滕琳[1] 马福懿[1] 

机构地区：[1]潍坊医学院附属潍坊市人民医院呼吸科,山东潍坊261041 [2]潍坊医学院附属潍坊市人民医院核医学科

出　　处：《潍坊医学院学报》2007年第6期503-505,共3页Acta Academiae Medicinae Weifang

摘　　要：目的探讨^(99m)TC-MIBI动态显像对非小细胞肺癌化疗疗效的预测价值。方法对确诊为不能手术的非小细胞肺癌患者化疗前,静脉注射740mbq ^(99m)TC-MIBI后分别于30min,2h行SPECT动态扫描,计算早期/晚期肿瘤组织与对侧正常肺组织的放射活性比(T/Ne,T/Nd),全身采用卡铂/顺铂+VP16化疗3周期,随后复查胸部CT,评判化疗疗效及其与^(99m)TC-MIBI动态显像的关系。结果78例NSCLC符合入选标准,并完成化疗方案,66例呈阳性显像,12例阴性显像,66例阳性显像中化疗有效率为90.7%,阴性显像12例中化疗全部进展,两者比较差异有显著性(P<0.01)。结论^(99m)TC-MIBI动态显像的放射活性越高,化疗效果越好,对非小细胞肺癌化疗疗效有预测价值,可为合理制定治疗方案提供重要依据。Objective To study the relationship between the early and delay ^99mTC-MIBI chest single photon emission computed tomography（SPECT） and the chemotherapy response. Methods Before chemotherapy, early and delay ^99mTC-MIBI chest SPECT was performed at 30min and 2 hours after iv 740mbq ^99mTC-MIBI. Assesment of MIBI uptake was done qualitatively and quantitatively calculate early and delay tumor：normal lung（T/Ne,T/Nd）. Patients were received cis-platin 60mg/m^2 or carpatin 300mg/m^2 iv D1 plus VP16 100mg iv D1-5 every 3～4 weeks. After 3 cycles of chemotherapy,the chemotherapy response was detected by chest CT. Results Seventy-eight patients with NSCLC were enrolled in this study. Postive imagine was 66, negative imagine was 12. In the postive 66 cases, the good-response was 61 ,meanwhile in the negative 12 cases the good-response was not found. The differences were significant（P 〈0.01 ）. Conclusion The ^99mTC-MIBI SPECT has the potential to predict chemotherapy response.

关 键 词：肺癌 非小细胞性 ^99MTC-MIBI 化疗 

分 类 号：R734.2[医药卫生—肿瘤]