Three-component one-pot synthesis of 1,2,3,4-tetrahydroquinoline derivatives in hexafluoroisopropanol  

作　　者：Jie Zhou Bai Ling Xu 

机构地区：[1]Institute of Materia Medica, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100050, China

出　　处：《Chinese Chemical Letters》2008年第8期921-924,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.30672540);NSF of Beijing(No.7072048)for financial support.

摘　　要：The one-pot aza-Diels-Alder reaction of substituted aromatic amines, ethyl glyoxylate and benzyl vinylcarbamate or N- benzyloxycarbonyl 2-pyrroline was conducted in hexafluoroisopropanol, providing the desired 1,2,3,4-tetrahydroquinline derivatives in moderate yields.The one-pot aza-Diels-Alder reaction of substituted aromatic amines, ethyl glyoxylate and benzyl vinylcarbamate or N- benzyloxycarbonyl 2-pyrroline was conducted in hexafluoroisopropanol, providing the desired 1,2,3,4-tetrahydroquinline derivatives in moderate yields.

关 键 词：Aza-Diels-Alder reaction TETRAHYDROQUINOLINE Hexafluoroisopropanol （HFIP） Fluorinated solvent 

分 类 号：O62[理学—有机化学]