核因子κB依赖的蛋白质精氨酸甲基转移酶1  

Nuclear factor-κB dependent protein arginine methyltransferase

作　　者：王翠莲[1] 楚东岭[1] 金发光[1] 

机构地区：[1]第四军医大学附属唐都医院呼吸科,西安 710038

出　　处：《国际呼吸杂志》2008年第15期947-949,共3页International Journal of Respiration

摘　　要：精氨酸甲基化参与信号转导、转录调控、染色质重塑和凋亡等多种细胞事件具有广泛的生物学功能。近年来蛋白质精氨酸甲基转移酶家族的新成员日益增多，目前已知有11个人类蛋白质精氨酸甲基转移酶。蛋白质精氨酸甲基转移酶可分成两型，Ⅰ型蛋白质精氨酸甲基转移酶催化生成单甲基精氨酸（MMA）和不对称二甲基精氨酸（ADMA），Ⅱ型蛋白质精氨酸甲基转移酶生成MMA和对称二甲基精氨酸。精氨酸甲基转移酶1是一个核因子κB（nuclear factor—κB，NF-κB）依赖的转录共激活因子，发挥启动子特异的募集NF-κB到染色质的调节因子功能。精氨酸甲基转移酶1可能主要通过增强募集NF-κB到相关位点激活NF-κB信号转导通路，启动了多种前炎性基因和免疫调节基因的转录，在免疫和炎症反应有关的基因转录调控中起关键作用。现在公认肺是NO的重要来源，在NO代谢中发挥重要的作用，肺也是一氧化氮合酶抑制剂ADMA的重要来源。ADMA作为假的底物竞争性抑制一氧化氮合酶活性，阻止内源性NO生成。作为ADMA和NO的主要来源，肺可能在精氨酸-甲基化精氨酸-NO这个重要而精细的平衡中起重要的作用。Arginine methylation involves in manifold cellular processes like signaling, transcription regulation,chromatin remolding, and apoptosis with extensive biology function. During recent years, new members of the family of protein arginine methyhransferases have been increasing, by now there are eleven protein arginine methyltransferases. Protein arginine methyltransferases are classified into two groups. Type protein arginine methyltransferases catalyze the formation of monomethylarginine and asymmetric dimethylarginine,type Ⅱ enzymes form monomethylarginine and symmetric dimethylarginine. Coactivatorassociated arginine methyltransferasel is a nuclear factor-κB（NF-κB） dependent transcriptional coactivator and functions as a promoter-specific regulator of NF-κB recruitment to chromatin. Coactivator-associated arginine methyhransferasel may activate NF-κB signal transduction pathway by enhancing NF-κB recruitment to cognate sites and initate transcriptional activation of a variety of proinflammatory and immunoregulation genes, which plays critical role in transcription regulation of immune and inflammatory reaction genes. Now it is generally accepted that lung is the major source of NO, plays an important role in NO metabolism,and acts as the major source of NOS inhibitor asymmetric dimethylarginine. Asymmetric dimethylarginine serves as false substrates and competitively inhibits NOS activity, blocking the formation of endogenous NO. As a major source of not only NO but also the NOS inhibitor asymmetric dimethylarginine, the lung likely plays a critical role in the important and delicate balance of arginine-methylarginine-NO.

关 键 词：精氨酸甲基转移酶1 核因子 ΚB 

分 类 号：Q[生物学]