大剂量纳洛酮加依达拉奉救治急性脑梗死的临床观察  

Clinical Observation on Treatment of Acute Cerebral Infarction with Large Dose of Edaravone Plus Naloxone

作　　者：李昌[1] 康德[1] 吴燕生[1] 

机构地区：[1]解放军第175医院急诊科,福建漳州363000

出　　处：《临床军医杂志》2008年第4期535-536,共2页Clinical Journal of Medical Officers

摘　　要：目的探讨大剂量纳洛酮加依达拉奉治疗急性脑梗死的临床效果。方法选择经头颅CT或MRI确诊的120例急性脑梗死患者随机分两组。治疗组给予纳洛酮4.0mg/d加依达拉奉30mg分别加至生理盐水250ml静滴1次/d,连用2周。对照组纳洛酮1.2mg/d加复方丹参液12ml静滴1次/d,连用2周。结果大剂量纳洛酮加依达拉奉(治疗组)用药后,总有效率明显优于对照组(P<0.01)。结论大剂量纳洛酮加依达拉奉对急性脑梗死有较好疗效。能促进神经功能恢复。具有脑保护及降低血黏度的作用。Objective To observe the clinical effect of large dose of naloxone plus edaravone on acute cerebral infarction. Methods A total of 120 patients with acute cerebral infarction confirmed by head CT or MRI were divided into two groups at random, i.e. trial group and control group. The trial group was treated with naloxone （4.0 mg） plus edaravone （30 mg） in physiological saline solution, and the control group with naloxone （1.2 mg） plus compound injection of red-rooted salvia （12 ml） by intravenous drip once per day for two weeks. Results The total effective rate was significantly higher in the trial group than in the control group （P〈0.01）. Conclusion Large dose of naloxone plus edaravone is effective on acaute cerbral infarction.

关 键 词：纳洛酮 依达拉奉 脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]