N,N-二甲氨基丙烯酸乙酯的合成  

Synthesis of Ethyl N, N-dimethylaminoacrylate

作　　者：王伟强 顾海宁[2] 汪劲松[3] 李小玲[3] 章鹏飞[4] 

机构地区：[1]浙江京新药业股份有限公司,浙江新昌312500 [2]浙江大学分析测试中心,杭州310028 [3]杭州广林生物医药有限公司,杭州310028 [4]杭州师范大学材料与化学化工学院,杭州310036

出　　处：《化工生产与技术》2008年第4期29-31,共3页Chemical Production and Technology

基　　金：国家支撑计划项目(2007BAI34B05);省绿色化工技术专项(2006C11023)

摘　　要：介绍了制备N,N-二甲氨基丙烯酸乙酯的亚胺络合法、一氧化碳高压合成法和羟醛缩合法及其优缺点。采用羟醛缩合法,即以甲酸乙酯与乙酸乙酯为原料,在金属钠或氢化钠存在下,经羟醛缩合生成甲酰基乙酸乙酯钠盐,再与二甲胺盐酸盐反应,合成目标产物。反应最佳温度25～30℃,较理想的溶剂为甲苯和二甲苯,总收率为60%。该方法反应条件温和、操作简单、原子经济性高、污染少,适合工业化生产。Synthetic routes of ethyl n,n-dimethylaminoacrylate, imine complexation, high-pressure of carbon monoxide synthesis, aldol condensation, are compared with their advantages and disadvantages. The method of aldol condensation is started from ethyl formate and ethyl acetate, reacted with sodium or sodium hydride, to obtain sodium ethyl formylacetate, then reacted with dimethylamine hydrochloride to obtain the final product. The total yield is 60%. This process has many advantages, such as mild reaction conditions, simple procedure, high atom economy and less pollution, so it is suitable for industrial production.

关 键 词：N N-甲氨基丙烯酸乙酯 甲酸乙酯 乙酸乙酯 喹诺酮 合成 

分 类 号：TQ225.24[化学工程—有机化工]