中低位直肠癌术后局部复发危险因素的临床病理研究  

Risk factors of local recurrence after curative resection in patients with middle and lo wer rectal carcinoma

作　　者：朱宝和[1] 侍立志[1] 黄建贤[1] 王甘露[1] 黄林[1] 黄冬凌[1] 

机构地区：[1]南方医科大学附属宝安人民医院普外科,广东深圳518101

出　　处：《中国民康医学》2008年第16期1819-1820,1839,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨中低位直肠癌根治性切除术后局部复发的危险因素。方法:分析2001年1月至2005年12月我院收治的行直肠系膜全切除(TME)的中低位直肠癌49例临床资料,分析局部复发与临床病理因素的关系。结果:中低位直肠癌根治性切除术后局部复发率为12.2%(6/49)。局部复发与肿瘤直径(P=0.011)、浸润深度(P=0.040)、分化程度(P=0.018)、淋巴结转移(P=0.041)、脉管侵袭(P=0.010)、环周切缘情况(P=0.017)和Dukes分期(P=0.021)显著相关,但与病人性别、年龄、系膜转移和手术方式不相关(P>0.05)。结论:肿瘤直径、浸润深度、分化程度、淋巴结转移、脉管侵袭、环周切缘情况和Dukes分期是直肠癌根治性切除术后局部复发的重要因素。Objective： To investigate the risk factors of local recurrence after curative resection in patients with middle and lower rectal carcinoma. Methods： Cancer specimens from 49 patients with middle and lower rectal carcinoma who received total mesorectal excision in our hospital from January of 2001 to December of 2005, The relationship between local recurrence and elinicopathologic characteristics of middle and lower rectal carcinoma was evaluated. Results： Local recurrence after curative resection occurred in 12.2% （6/49） of patients with middle and lower rectal carcinoma. Local recurrence was associated with tumor size （ P = 0.011 ）, infilt rating depth （ P = 0.040）, tumor differentiation （ P = 0.018）, lymph node metastasis （ P = 0.041）, vessel cancerous emboli （ P = 0.010）, circumferential resection margin stat us （ P = 0.017） and Dukes staging （ P = 0.021）, but had no association with patients＇ sex and age, mesorectal metastasis and modus operandi. Conclusion： The results demonstrate that tumor size,infiltrating depth, tumor differentiation, lymph node metastasis, vessel cancerous emboli, circumferential resection margin status and Dukes staging are significant risk factors of local recurrence after curative resection in patients with middle and lower rectal carcinoma.

关 键 词：中低位直肠癌 根治性切除术 复发 

分 类 号：R735.37[医药卫生—肿瘤]