去胸腺大鼠模型的建立方法  

Method of Establishing The Model of Thymectomy in Adult Rats

作　　者：王谦[1] 李立[1] 陈刚[1] 李晓延[1] 闫宏宪[1] 

机构地区：[1]昆明市第一人民医院暨昆明医学院附属甘美医院肝移植中心,昆明650011

出　　处：《中国普外基础与临床杂志》2008年第8期579-580,共2页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探索建立大鼠胸腺切除模型的方法。方法采用Sprague-Dawley(SD)大鼠,在开胸切除胸腺的同时配合术中剑突下抽气的方法建立模型,正式实验30次。结果30只大鼠中,1只死于术后肺不张,1只因术中误穿肺静脉失血过多而死亡。余28只均存活30d,手术成功率达93.3%。结论改进的大鼠胸腺切除术操作简便,手术成功率较高,可作为可靠、稳定的动物模型。Objective To establish model of thymectomy in adult rats. Methods The animal models were built by resection of the thymus and simuhaneously emptying the air under xiphoid in the rats underwent thoracotomy. Results Of 30 rats, 1 died of postoperative atelectasis, 1 died of excessive bleeding because of puncturing the pulmonary vein by mistake during the operation. Twenty-eight rats survived more than 30 days. A successful rate of 93.3% was achieved in the making of tbymectomy model. Conclusion The results show that the model is easy to operate and the success rate is very high, and can be used in the experiment of thymectomy in the rats.

关 键 词：大鼠 手术 胸腺切除 

分 类 号：R-332[医药卫生]