幽门螺杆菌感染及环氧合酶-2表达与胃癌变的关系  

Correlation between H.pylori infection and COX-2 protein expression in gastric cancer and precancerous lesion

作　　者：陈随才[1] 刘小玉[1] 韩国宏[2] 

机构地区：[1]榆林市第二医院消化内科,陕西榆林719000 [2]第四军医大学西京医院消化内科,陕西西安710033

出　　处：《第四军医大学学报》2008年第16期1515-1517,共3页Journal of the Fourth Military Medical University

摘　　要：目的:探讨胃黏膜幽门螺杆菌(helicobactor pylori,H.pylori)感染、环氧合酶-2(COX-2)的表达与胃癌发生、发展的关系.方法:胃癌(GC)标本80例,非典型增生(Dys)40例,萎缩性胃炎(CAG)30例,肠上皮化生(IM)30例,浅表性胃炎(CSG)30例,应用免疫组化方法测定COX-2蛋白的表达,用亚甲兰染色检测H.pylori.结果:CSG,GC中H.pylori阳性和阴性病例COX-2表达差异无统计学意义(P>0.05),但在CAG,IM,Dys中的H.pylori阳性病例中COX-2表达高于H.pylori阴性病例(52.9%vs7.6%,52.6%vs9.0%,67.9%vs33.3%).结论:H.pylori感染诱导COX-2表达发生在胃癌形成的早期阶段.AIM： To investigate the relationship between helicobacter pylori （ H. Fylori ） infection and cyclooxygenase-2 （ COX-2 ） expression in gastric cancer and precancerous lesions, and to study the possible role of H. pylori infection in gastric cancinogenesis. METHODS： In 30 cases of chronic superficial gastritis （CSG）, 30 cases of chronic atrophic gastritis（ CAG）, 30 cases of intestina metaplasia （ IM ）, 40 cases of atypical dysplasia （ Dys ） and 80 cases of gastric carcinoma（GC） , the expression of COX-2 protein was detected by immunohistochemistry and H. pylori infection was examined by Methylene Blue staining. RESULTS： In CSG and GC, there was no significant difference in the positivity rate of COX-2 between H. pylori positive and negative patients （P 〉0.05 ）. In CAG, IM and Dys, COX-2 protein expression level was increased in H. pylori positive patients when compared with H. pylori negative patients （ 52. 9% vs 7. 6% , 52. 6% vs 9.0% ,67.9% vs 33.3% ）. CONCLUSION ： The expression of COX-2 is upregulated in the process of gastric cancer. COX-2 may be helpful to the early diagnosis of gastric cancer.

关 键 词：胃肿瘤 癌前状态 螺杆菌 幽门 前列腺素内过氧化物合酶 

分 类 号：R735.2[医药卫生—肿瘤]