富于淋巴细胞浆细胞型脑膜瘤2例及其文献复习  

Lymphoplasmoacyte-rich meningioma:A report of two cases and review of literature

作　　者：王绪明[1] 李凡彩[1] 陆明深[1] 候巧燕[1] 张美艳[1] 陈峰[1] 

机构地区：[1]桂林医学院病理学教研室,桂林541001

出　　处：《华中医学杂志》2008年第4期254-256,共3页Central China Medical Journal

摘　　要：目的探讨富于淋巴细胞浆细胞型脑膜瘤的临床病理学特征。方法对2例富于淋巴细胞浆细胞型脑膜瘤进行光镜观察及免疫组织化学标记,并通过文献复习,对病理诊断及鉴别诊断等指标进行分析。结果2例患者均为女性,1例发生于左枕底部,1例发生于右顶叶。光镜下纤维型细胞束平行或交错排列,密集的淋巴细胞、浆细胞浸润,局灶出现淋巴滤泡。免疫表型:肿瘤细胞EMA(+)、Vim(+)、S-100(+)、PAS(+)、GFAP(-);淋巴细胞表达T细胞和B细胞抗原,CD3(+)、CD45RO(+)、CD20(+)、CD79a(+)、Bcl-2(-)、CyclinD1(-)。结论本肿瘤是脑膜瘤变异型之一,在脑膜瘤组织内存在有大量的淋巴浆细胞浸润。免疫组织化学显示浸润的主要是淋巴浆细胞,γ-球蛋白血症/贫血与本病发生及复发有一定的联系。诊断时需与颅内恶性淋巴瘤、原始神经外胚叶肿瘤、炎性假瘤等鉴别。Objective To investigate the clinicopathological characteristics of lymphoplasmocyte-rich meningioma. Methods The histopathology and irnmunophenotype of 2 cases of lymphoplasmocyte-rich meningioma were studied in order to analyze its diagnostic and differential diagnostic factors. Results The two patients were women. One tumor occurred in the bottom of the left occiput of the brain and another in the lobi parietalis of the brain. Microscopically, the fibrous type cell arranged in strands and cords with more lymphocyte infiltreation. Folliculi lymphaticus occurred in local areas. Irnmunohistochemistry showed that the tumor of case 1 and case 2 were postive for EMA（ ＋ ）, Vim（ ＋ ）, S-100（ ＋ ）, PAS（ ＋ ）, CD3 （ ＋ ）, CD45RO （ ＋ ） ,CD20（ ＋ ） ,CD79a（ ＋ ） ,but negative for GFAP, Bcl-2, CyclinD1. Conclusion The tumor is one kind of the meningioma with varied forms. Many lymphocytes infictrate in the tumor. Irnmunohistochemistry showed that most of the lymphocytes are phlogocytes. The glohulinemia and the anemia is associated with the occurrence and recurrence of the tumor to some extent. Differential diagnosis includes the brain-lymphodenoma, primitive neuroectodermal tumor, inflammatory pseudotumor, and so on.

关 键 词：富于淋巴细胞浆细胞型脑膜瘤 鉴别诊断 免疫组织化学 

分 类 号：R739.45[医药卫生—肿瘤]