抗抑郁药对胰腺癌移植瘤模型的进食及肿瘤生长的影响  

Effect of antidepressants on food intake and tumor growth in a xenograft mouse model of human pancreatic cancer

作　　者：尚鸳鸳[1] 贾林[1] 

机构地区：[1]广州医学院附属市一人民医院、广州市第一人民医院消化内科,广东广州510180

出　　处：《中华胰腺病杂志》2008年第4期227-229,共3页Chinese Journal of Pancreatology

基　　金：2006年广东省社会发展领域科技计划项目（63082）

摘　　要：目的探讨米氮平和氟西汀对胰腺癌皮下移植瘤裸鼠进食量、体重和肿瘤生长的影响。方法建立21只人胰腺癌细胞SW1990的裸鼠皮下移植瘤动物模型，按完全随机法分为对照组、米氮平组和氟西汀组，各7只。建模后1d开始分别给各组生理盐水、米氮平10mg·kg^-1·d^-1和氟西汀10mg·kg^-1·d^-1灌胃，每天1次，持续42d。比较3组裸鼠进食量、体重和肿瘤体积的变化。结果3组胰腺癌移植瘤体积无明显差异。第2周米氮平组进食量为（5．03±0．16）g，显著较其他2组多，第4周体重为（16．00±1．41）g，较其他2组下降少（P〈0．05）；氟西汀组从第3周起进食量较对照组显著减少，第6周的体重也较对照组显著下降（P〈0．05）。在第6周，对照组、米氮平组和氟西汀组的日进食量分别为（3．54±0．13）g、（4．19±0．16）g和（3．34±0．13）g，体重分别为（13．71±1．11）g、（14．86±1．68）g和（12．57±1．51）g。结论米氮平在改善荷瘤裸鼠进食量和减缓体重下降方面优于氟西汀，但两者对肿瘤生长均无明显影响。Objective To investigate the effect of different antidepressants （mirtazapine and fluoxetine） on food intake, body weight, tumor growth in a mouse model of pancreatic cancer. Methods A subcutaneous xenograft mouse model of human pancreatic cancer SW1990 was established. The tumor-bearing mice were randomly divided into saline solution control group, mirtazapine group, fluoxetine group, with 7 mice in each group. All mice were treated once daily with saline solution, mirtazapine （ 10 mg·kg^-1·d^-1）, fluoxetine （ 10mg·kg^-1·d^-1 ）, orally by using metal gavage feeding needles for 42 days. Tumor size, body weight, food intake were investigated. Results There was no significant difference in tumor size in the three groups. From the 2nd week, the food intake of mice in the mirtazapine group significantly increased compared with other two groups; the body weight of mice in the mirtazapine group at the 4th week was （ 16.00 ± 1.41 ） g, which was higher than those in other two groups （P 〈 0.05 ） ; from the 3rd week, the food intake of mice in the fluoxetine group significantly decreased compared with control group, and the body weight also decreased significantly from the 6th week （P 〈 0.05） ; at the 6th week, the food intake of mice in the control, mirtazapine and fluoxetine groups were （3.54±0.13） g, （4.19±0.16） g and （3.34±0.13） g, and the body weight were （13.71±1.11） g, （14.86 ±1.68） gand （12.57 ±1.51） g, respectively. Conclusions Mirtazapine was better than fluoxetine in increasing food intake and alleviating body decreasing on a pancreatic cancer mouse model. However, there was no significant effect on the pancreatic tumor growth.

关 键 词：胰腺肿瘤 抗抑郁药 米氮平 氟西汀 小鼠 裸 

分 类 号：R749.4[医药卫生—神经病学与精神病学]